Protein interactions with piALU RNA indicates putative participation of retroRNA in the cell cycle, DNA repair and chromatin assembly

Recent analyses suggest that transposable element-derived transcripts are processed to yield a variety of small RNA species that play critical functional roles in gene regulation and chromatin organization as well as genome stability and maintenance. Here we report a mass spectrometry analysis of an...

Descripción completa

Detalles Bibliográficos
Autores principales: Blackwell, Benjamin J., Lopez, Mary F., Wang, Jianrong, Krastins, Bryan, Sarracino, David, Tollervey, James R., Dobke, Marek, Jordan, I. King, Lunyak, Victoria V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383447/
https://www.ncbi.nlm.nih.gov/pubmed/22754750
http://dx.doi.org/10.4161/mge.19032
Descripción
Sumario:Recent analyses suggest that transposable element-derived transcripts are processed to yield a variety of small RNA species that play critical functional roles in gene regulation and chromatin organization as well as genome stability and maintenance. Here we report a mass spectrometry analysis of an RNA-affinity complex isolation using a piRNA homologous sequence derived from Alu retrotransposal RNA. Our data point to potential roles for piALU RNAs in DNA repair, cell cycle and chromatin regulations.

Ejemplares similares