In silico analysis of sequenced strains of Clostridium difficile reveals a related set of conjugative transposons carrying a variety of accessory genes

The human gut pathogen Clostridium difficile contains many conjugative transposons that have an array of accessory genes. In the current study, recently sequenced genomes were analyzed to identify new putative conjugative transposons. Eleven new elements in 5 C. difficile strains were identified and...

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Detalles Bibliográficos
Autores principales: Brouwer, Michael S.M., Roberts, Adam P., Mullany, Peter, Allan, Elaine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383454/
https://www.ncbi.nlm.nih.gov/pubmed/22754747
http://dx.doi.org/10.4161/mge.19297
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author Brouwer, Michael S.M.
Roberts, Adam P.
Mullany, Peter
Allan, Elaine
author_facet Brouwer, Michael S.M.
Roberts, Adam P.
Mullany, Peter
Allan, Elaine
author_sort Brouwer, Michael S.M.
collection PubMed
description The human gut pathogen Clostridium difficile contains many conjugative transposons that have an array of accessory genes. In the current study, recently sequenced genomes were analyzed to identify new putative conjugative transposons. Eleven new elements in 5 C. difficile strains were identified and all had a similar structure to the previously described elements CTn1, CTn5 and CTn7 in C. difficile strain 630. Each element identified did however contain a new set of accessory genes compared with those previously reported; including those predicted to encode ABC transporters, a toxin/antitoxin system and multiple antibiotic resistance genes.
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spelling pubmed-33834542012-06-29 In silico analysis of sequenced strains of Clostridium difficile reveals a related set of conjugative transposons carrying a variety of accessory genes Brouwer, Michael S.M. Roberts, Adam P. Mullany, Peter Allan, Elaine Mob Genet Elements Letter to the Editor The human gut pathogen Clostridium difficile contains many conjugative transposons that have an array of accessory genes. In the current study, recently sequenced genomes were analyzed to identify new putative conjugative transposons. Eleven new elements in 5 C. difficile strains were identified and all had a similar structure to the previously described elements CTn1, CTn5 and CTn7 in C. difficile strain 630. Each element identified did however contain a new set of accessory genes compared with those previously reported; including those predicted to encode ABC transporters, a toxin/antitoxin system and multiple antibiotic resistance genes. Landes Bioscience 2012-01-01 /pmc/articles/PMC3383454/ /pubmed/22754747 http://dx.doi.org/10.4161/mge.19297 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Letter to the Editor
Brouwer, Michael S.M.
Roberts, Adam P.
Mullany, Peter
Allan, Elaine
In silico analysis of sequenced strains of Clostridium difficile reveals a related set of conjugative transposons carrying a variety of accessory genes
title In silico analysis of sequenced strains of Clostridium difficile reveals a related set of conjugative transposons carrying a variety of accessory genes
title_full In silico analysis of sequenced strains of Clostridium difficile reveals a related set of conjugative transposons carrying a variety of accessory genes
title_fullStr In silico analysis of sequenced strains of Clostridium difficile reveals a related set of conjugative transposons carrying a variety of accessory genes
title_full_unstemmed In silico analysis of sequenced strains of Clostridium difficile reveals a related set of conjugative transposons carrying a variety of accessory genes
title_short In silico analysis of sequenced strains of Clostridium difficile reveals a related set of conjugative transposons carrying a variety of accessory genes
title_sort in silico analysis of sequenced strains of clostridium difficile reveals a related set of conjugative transposons carrying a variety of accessory genes
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383454/
https://www.ncbi.nlm.nih.gov/pubmed/22754747
http://dx.doi.org/10.4161/mge.19297
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