Cargando…

Satellite Cells Derived from Obese Humans with Type 2 Diabetes and Differentiated into Myocytes In Vitro Exhibit Abnormal Response to IL-6

Obesity and type 2 diabetes are associated with chronically elevated systemic levels of IL-6, a pro-inflammatory cytokine with a role in skeletal muscle metabolism that signals through the IL-6 receptor (IL-6Rα). We hypothesized that skeletal muscle in obesity-associated type 2 diabetes develops a r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scheele, Camilla, Nielsen, Søren, Kelly, Meghan, Broholm, Christa, Nielsen, Anders Rinnov, Taudorf, Sarah, Pedersen, Maria, Fischer, Christian P., Pedersen, Bente Klarlund
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383673/ https://www.ncbi.nlm.nih.gov/pubmed/22761857 http://dx.doi.org/10.1371/journal.pone.0039657

Ejemplares similares

Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes
por: Väremo, Leif, et al.
Publicado: (2017)

Fibroblast Growth Factor-21 Is Induced in Human Skeletal Muscles by Hyperinsulinemia
por: Hojman, Pernille, et al.
Publicado: (2009)

The miRNA Plasma Signature in Response to Acute Aerobic Exercise and Endurance Training
por: Nielsen, Søren, et al.
Publicado: (2014)

Calprotectin — A Novel Marker of Obesity
por: Mortensen, Ole Hartvig, et al.
Publicado: (2009)

Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes
por: Davegårdh, Cajsa, et al.
Publicado: (2019)

Elevated NF-κB Activation Is Conserved in Human Myocytes Cultured From Obese Type 2 Diabetic Patients and Attenuated by AMP-Activated Protein Kinase
por: Green, Charlotte J., et al.
Publicado: (2011)

Insulin signaling in skeletal muscle of HIV-infected patients in response to endurance and strength training
por: Broholm, Christa, et al.
Publicado: (2013)

Lifelong Physical Activity Prevents Aging-Associated Insulin Resistance in Human Skeletal Muscle Myotubes via Increased Glucose Transporter Expression
por: Bunprajun, Tipwadee, et al.
Publicado: (2013)

Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects
por: Davegårdh, Cajsa, et al.
Publicado: (2017)

In Vitro Palmitate Treatment of Myotubes from Postmenopausal Women Leads to Ceramide Accumulation, Inflammation and Affected Insulin Signaling
por: Abildgaard, Julie, et al.
Publicado: (2014)

Cerebral net exchange of Brain-Derived Neurotrophic Factor (BDNF) during experimental systemic inflammation and hypoxaemia in humans
por: Berg, Ronan MG, et al.
Publicado: (2009)

Muscle specific miRNAs are induced by testosterone and independently upregulated by age
por: Nielsen, Søren, et al.
Publicado: (2014)

Single Cell Analysis Identifies the miRNA Expression Profile of a Subpopulation of Muscle Precursor Cells Unique to Humans With Type 2 Diabetes
por: Henriksen, Tora I., et al.
Publicado: (2018)

Human visceral and subcutaneous adipose stem and progenitor cells retain depot-specific adipogenic properties during obesity
por: Mathur, Neha, et al.
Publicado: (2022)

Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans
por: Berg, Ronan MG, et al.
Publicado: (2010)

Plasma YKL-40: A BMI-Independent Marker of Type 2 Diabetes
por: Nielsen, Anders R., et al.
Publicado: (2008)

Dysregulation of a novel miR-23b/27b-p53 axis impairs muscle stem cell differentiation of humans with type 2 diabetes
por: Henriksen, Tora I., et al.
Publicado: (2017)

Obesity and Low-Grade Inflammation Increase Plasma Follistatin-Like 3 in Humans
por: Brandt, Claus, et al.
Publicado: (2014)

Exercise as a Mean to Control Low-Grade Systemic Inflammation
por: Mathur, Neha, et al.
Publicado: (2008)

Type 2 Diabetes Is Associated with Altered NF-κB DNA Binding Activity, JNK Phosphorylation, and AMPK Phosphorylation in Skeletal Muscle after LPS
por: Andreasen, Anne Sofie, et al.
Publicado: (2011)

Metabolic regulation and the anti-obesity perspectives of human brown fat
por: Scheele, Camilla, et al.
Publicado: (2017)

Muscle-Organ Crosstalk: Focus on Immunometabolism
por: Bay, Marie Lund, et al.
Publicado: (2020)

Development of Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease: Smoking, Inflammation, or Simply Disuse?
por: Iepsen, Ulrik Winning, et al.
Publicado: (2020)

Exercise suppresses tumor growth through epinephrine- and IL-6-dependent mobilization and redistribution of NK cells
por: Pedersen, Line, et al.
Publicado: (2015)

Muscle–Organ Crosstalk: The Emerging Roles of Myokines
por: Severinsen, Mai Charlotte Krogh, et al.
Publicado: (2020)

Effect of endurance versus resistance training on quadriceps muscle dysfunction in COPD: a pilot study
por: Iepsen, Ulrik Winning, et al.
Publicado: (2016)

Pretransplant serum levels of endothelial cell activation markers are associated with graft loss and mortality after kidney transplantation
por: Lund, Kit Peiter, et al.
Publicado: (2022)

Low expression of IL-18 and IL-18 receptor in human skeletal muscle is associated with systemic and intramuscular lipid metabolism—Role of HIV lipodystrophy
por: Lindegaard, Birgitte, et al.
Publicado: (2018)

Correction: Low expression of IL-18 and IL-18 receptor in human skeletal muscle is associated with systemic and intramuscular lipid metabolism—Role of HIV lipodystrophy
por: Lindegaard, Birgitte, et al.
Publicado: (2018)

The Acute Effects of Low-Dose TNF-α on Glucose Metabolism and β-Cell Function in Humans
por: Ibfelt, Tobias, et al.
Publicado: (2014)

Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes
por: Gallagher, Iain J, et al.
Publicado: (2010)

Interleukin‐6 myokine signaling in skeletal muscle: a double‐edged sword?
por: Muñoz‐Cánoves, Pura, et al.
Publicado: (2013)

Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men
por: Trinh, Beckey, et al.
Publicado: (2021)

Erythropoietin Over-Expression Protects against Diet-Induced Obesity in Mice through Increased Fat Oxidation in Muscles
por: Hojman, Pernille, et al.
Publicado: (2009)

Cancer risk in relation to body fat distribution, evaluated by DXA-scans, in postmenopausal women – the Prospective Epidemiological Risk Factor (PERF) study
por: Staunstrup, Line Mærsk, et al.
Publicado: (2019)

Plasma and Muscle Myostatin in Relation to Type 2 Diabetes
por: Brandt, Claus, et al.
Publicado: (2012)

Cognitive Functions in Middle Aged Individuals Are Related to Metabolic Disturbances and Aerobic Capacity: A Cross-Sectional Study
por: Pedersen, Maria, et al.
Publicado: (2012)

Long-term effect of smartphone-delivered Interval Walking Training on physical activity in patients with type 2 diabetes: protocol for a parallel group single-blinded randomised controlled trial
por: Valentiner, Laura Staun, et al.
Publicado: (2017)

The effect of glutamine infusion on the inflammatory response and HSP70 during human experimental endotoxaemia
por: Andreasen, Anne Sofie, et al.
Publicado: (2009)

Environmental risk factors differ between rheumatoid arthritis with and without auto-antibodies against cyclic citrullinated peptides
por: Pedersen, Merete, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_ru6hf6vt4glggccbm7hs5t4u8g