Complement Inhibition Promotes Endogenous Neurogenesis and Sustained Anti-Inflammatory Neuroprotection following Reperfused Stroke

BACKGROUND AND PURPOSE: The restoration of blood-flow following cerebral ischemia incites a series of deleterious cascades that exacerbate neuronal injury. Pharmacologic inhibition of the C3a-receptor ameliorates cerebral injury by attenuating post-ischemic inflammation. Recent reports also implicat...

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Detalles Bibliográficos
Autores principales: Ducruet, Andrew F., Zacharia, Brad E., Sosunov, Sergey A., Gigante, Paul R., Yeh, Mason L., Gorski, Justin W., Otten, Marc L., Hwang, Richard Y., DeRosa, Peter A., Hickman, Zachary L., Sergot, Paulina, Connolly, E. Sander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383680/
https://www.ncbi.nlm.nih.gov/pubmed/22761695
http://dx.doi.org/10.1371/journal.pone.0038664

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