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Role of IKK/NF-κB Signaling in Extinction of Conditioned Place Aversion Memory in Rats

The inhibitor κB protein kinase/nuclear factor κB (IKK/NF-κB) signaling pathway is critical for synaptic plasticity. However, the role of IKK/NF-κB in drug withdrawal-associated conditioned place aversion (CPA) memory is unknown. Here, we showed that inhibition of IKK/NF-κB by sulphasalazine (SSZ; 1...

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Autores principales: Yang, Cheng-Hao, Liu, Xiang-Ming, Si, Ji-Jian, Shi, Hai-Shui, Xue, Yan-Xue, Liu, Jian-Feng, Luo, Yi-Xiao, Chen, Chen, Li, Peng, Yang, Jian-Li, Wu, Ping, Lu, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383688/
https://www.ncbi.nlm.nih.gov/pubmed/22761874
http://dx.doi.org/10.1371/journal.pone.0039696
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author Yang, Cheng-Hao
Liu, Xiang-Ming
Si, Ji-Jian
Shi, Hai-Shui
Xue, Yan-Xue
Liu, Jian-Feng
Luo, Yi-Xiao
Chen, Chen
Li, Peng
Yang, Jian-Li
Wu, Ping
Lu, Lin
author_facet Yang, Cheng-Hao
Liu, Xiang-Ming
Si, Ji-Jian
Shi, Hai-Shui
Xue, Yan-Xue
Liu, Jian-Feng
Luo, Yi-Xiao
Chen, Chen
Li, Peng
Yang, Jian-Li
Wu, Ping
Lu, Lin
author_sort Yang, Cheng-Hao
collection PubMed
description The inhibitor κB protein kinase/nuclear factor κB (IKK/NF-κB) signaling pathway is critical for synaptic plasticity. However, the role of IKK/NF-κB in drug withdrawal-associated conditioned place aversion (CPA) memory is unknown. Here, we showed that inhibition of IKK/NF-κB by sulphasalazine (SSZ; 10 mM, i.c.v.) selectively blocked the extinction but not acquisition or expression of morphine-induced CPA in rats. The blockade of CPA extinction induced by SSZ was abolished by sodium butyrate, an inhibitor of histone deacetylase. Thus, the IKK/NF-κB signaling pathway might play a critical role in the extinction of morphine-induced CPA in rats and might be a potential pharmacotherapy target for opiate addiction.
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spelling pubmed-33836882012-07-03 Role of IKK/NF-κB Signaling in Extinction of Conditioned Place Aversion Memory in Rats Yang, Cheng-Hao Liu, Xiang-Ming Si, Ji-Jian Shi, Hai-Shui Xue, Yan-Xue Liu, Jian-Feng Luo, Yi-Xiao Chen, Chen Li, Peng Yang, Jian-Li Wu, Ping Lu, Lin PLoS One Research Article The inhibitor κB protein kinase/nuclear factor κB (IKK/NF-κB) signaling pathway is critical for synaptic plasticity. However, the role of IKK/NF-κB in drug withdrawal-associated conditioned place aversion (CPA) memory is unknown. Here, we showed that inhibition of IKK/NF-κB by sulphasalazine (SSZ; 10 mM, i.c.v.) selectively blocked the extinction but not acquisition or expression of morphine-induced CPA in rats. The blockade of CPA extinction induced by SSZ was abolished by sodium butyrate, an inhibitor of histone deacetylase. Thus, the IKK/NF-κB signaling pathway might play a critical role in the extinction of morphine-induced CPA in rats and might be a potential pharmacotherapy target for opiate addiction. Public Library of Science 2012-06-26 /pmc/articles/PMC3383688/ /pubmed/22761874 http://dx.doi.org/10.1371/journal.pone.0039696 Text en Yang et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Yang, Cheng-Hao
Liu, Xiang-Ming
Si, Ji-Jian
Shi, Hai-Shui
Xue, Yan-Xue
Liu, Jian-Feng
Luo, Yi-Xiao
Chen, Chen
Li, Peng
Yang, Jian-Li
Wu, Ping
Lu, Lin
Role of IKK/NF-κB Signaling in Extinction of Conditioned Place Aversion Memory in Rats
title Role of IKK/NF-κB Signaling in Extinction of Conditioned Place Aversion Memory in Rats
title_full Role of IKK/NF-κB Signaling in Extinction of Conditioned Place Aversion Memory in Rats
title_fullStr Role of IKK/NF-κB Signaling in Extinction of Conditioned Place Aversion Memory in Rats
title_full_unstemmed Role of IKK/NF-κB Signaling in Extinction of Conditioned Place Aversion Memory in Rats
title_short Role of IKK/NF-κB Signaling in Extinction of Conditioned Place Aversion Memory in Rats
title_sort role of ikk/nf-κb signaling in extinction of conditioned place aversion memory in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383688/
https://www.ncbi.nlm.nih.gov/pubmed/22761874
http://dx.doi.org/10.1371/journal.pone.0039696
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