Down-Regulation of HtrA1 Activates the Epithelial-Mesenchymal Transition and ATM DNA Damage Response Pathways

Expression of the serine protease HtrA1 is decreased or abrogated in a variety of human primary cancers, and higher levels of HtrA1 expression are directly related to better response to chemotherapeutics. However, the precise mechanisms leading to HtrA1 down regulation during malignant transformatio...

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Detalles Bibliográficos
Autores principales: Wang, Ning, Eckert, Kristin A., Zomorrodi, Ali R., Xin, Ping, Pan, Weihua, Shearer, Debra A., Weisz, Judith, Maranus, Costas D., Clawson, Gary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383700/
https://www.ncbi.nlm.nih.gov/pubmed/22761798
http://dx.doi.org/10.1371/journal.pone.0039446

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