Cargando…

Effects of Activin and TGFβ on p21 in Colon Cancer

Activin and TGFβ share SMAD signaling and colon cancers can inactivate either pathway alone or simultaneously. The differential effects of activin and TGFβ signaling in colon cancer have not been previously dissected. A key downstream target of TGFβ signaling is the cdk2 inhibitor p21 (p21(cip1/waf1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bauer, Jessica, Sporn, Judith C., Cabral, Jennifer, Gomez, Jessica, Jung, Barbara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383701/ https://www.ncbi.nlm.nih.gov/pubmed/22761777 http://dx.doi.org/10.1371/journal.pone.0039381

Ejemplares similares

Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer
por: Bauer, Jessica, et al.
Publicado: (2015)

Activin Signaling in Microsatellite Stable Colon Cancers Is Disrupted by a Combination of Genetic and Epigenetic Mechanisms
por: Jung, Barbara, et al.
Publicado: (2009)

Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer
por: Staudacher, Jonas J., et al.
Publicado: (2017)

An autocrine ActivinB mechanism drives TGFβ/Activin signaling in Group 3 medulloblastoma
por: Morabito, Morgane, et al.
Publicado: (2019)

Different Immunoregulation Roles of Activin A Compared With TGF-β
por: Li, Fanglin, et al.
Publicado: (2022)

Activin E is a TGFβ ligand that signals specifically through activin receptor-like kinase 7
por: Vestal, Kylie A, et al.
Publicado: (2023)

Nuclear translocation of Atox1 potentiates activin A-induced cell migration and colony formation in colon cancer
por: Jana, Arundhati, et al.
Publicado: (2020)

TGFβ and activin A control regulatory T cells in irradiated tumors
por: Vanpouille-Box, Claire, et al.
Publicado: (2015)

Increased stiffness of the tumor microenvironment in colon cancer stimulates cancer associated fibroblast-mediated prometastatic activin A signaling
por: Bauer, Jessica, et al.
Publicado: (2020)

Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors
por: Olsen, Oddrun Elise, et al.
Publicado: (2020)

Author Correction: Increased stiffness of the tumor microenvironment in colon cancer stimulates cancer associated fibroblast-mediated prometastatic activin A signaling
por: Bauer, Jessica, et al.
Publicado: (2020)

Intertwining of Activin A and TGFβ Signaling: Dual Roles in Cancer Progression and Cancer Cell Invasion
por: Loomans, Holli A., et al.
Publicado: (2014)

Loss of TGFβ signaling promotes colon cancer progression and tumor-associated inflammation
por: Principe, Daniel R., et al.
Publicado: (2016)

Role of stromal activin A in human pancreatic cancer and metastasis in mice
por: Mancinelli, Georgina, et al.
Publicado: (2021)

TGF-β/activin signaling promotes CDK7 inhibitor resistance in triple-negative breast cancer cells through upregulation of multidrug transporters
por: Webb, Bryan M., et al.
Publicado: (2021)

VprBP mitigates TGF-β and Activin signaling by promoting Smurf1-mediated type I receptor degradation
por: Li, Yihao, et al.
Publicado: (2019)

TGFβ/Activin signalling is required for ribosome biogenesis and cell growth in Drosophila salivary glands
por: Martins, Torcato, et al.
Publicado: (2017)

A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling
por: Soomro, Asfia, et al.
Publicado: (2023)

Invasion of ovarian cancer cells is induced byPITX2-mediated activation of TGF-β and Activin-A
por: Basu, Moitri, et al.
Publicado: (2015)

p63 and Its Target Follistatin Maintain Salivary Gland Stem/Progenitor Cell Function through TGF-β/Activin Signaling
por: Min, Sangwon, et al.
Publicado: (2020)

Expression of an Oncogenic BARD1 Splice Variant Impairs Homologous Recombination and Predicts Response to PARP-1 Inhibitor Therapy in Colon Cancer
por: Ozden, Ozkan, et al.
Publicado: (2016)

TGF-beta expression in the human colon: differential immunostaining along crypt epithelium.
por: Avery, A., et al.
Publicado: (1993)

Activin A backs-up TGF-ß to promote regulatory T cells
por: De Martino, Mara, et al.
Publicado: (2021)

Structures of activin ligand traps using natural sets of type I and type II TGFβ receptors
por: Goebel, Erich J., et al.
Publicado: (2021)

Activin in acute pancreatitis: Potential risk-stratifying marker and novel therapeutic target
por: Staudacher, Jonas J., et al.
Publicado: (2017)

Induction of primitive streak and mesendoderm formation in monolayer hESC culture by activation of TGF-β signaling pathway by Activin B
por: Mahmood, Amer, et al.
Publicado: (2015)

NFkB is essential for activin-induced colorectal cancer migration via upregulation of PI3K-MDM2 pathway
por: Jana, Arundhati, et al.
Publicado: (2017)

Activins and their related proteins in colon carcinogenesis: insights from early and advanced azoxymethane rat models of colon cancer
por: Refaat, Bassem, et al.
Publicado: (2016)

Activin B and Activin C Have Opposing Effects on Prostate Cancer Progression and Cell Growth
por: Reader, Karen L., et al.
Publicado: (2022)

The syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGFβ and Activin pathways
por: García, Marta, et al.
Publicado: (2017)

Different phenotypes and chondrogenic responses of human menstrual blood and bone marrow mesenchymal stem cells to activin A and TGF-β3
por: Uzieliene, Ilona, et al.
Publicado: (2021)

Signaling through the TGF Beta-Activin Receptors ALK4/5/7 Regulates Testis Formation and Male Germ Cell Development
por: Miles, Denise C., et al.
Publicado: (2013)

The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of activin A/TGFβ and β1 integrin signalling
por: Morris, Mhairi A., et al.
Publicado: (2016)

Systemic Activin Is Elevated in Patients With Severe Alcoholic Hepatitis
por: STAUDACHER, J. J., et al.
Publicado: (2022)

BRD9-mediated control of the TGF-β/Activin/Nodal pathway regulates self-renewal and differentiation of human embryonic stem cells and progression of cancer cells
por: Wang, Xuepeng, et al.
Publicado: (2023)

TGF-β-induced hepatocyte lincRNA-p21 contributes to liver fibrosis in mice
por: Tu, Xiaolong, et al.
Publicado: (2017)

Reduction of Activin Receptor-Like Kinase 4 Expression Ameliorates Myocardial Ischemia/Reperfusion Injury through Inhibiting TGFβ Signaling Pathway
por: Chen, Mantian, et al.
Publicado: (2022)

Activin A Modulates Inflammation in Acute Pancreatitis and Strongly Predicts Severe Disease Independent of Body Mass Index
por: Thomas, Alexandra L., et al.
Publicado: (2020)

A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells
por: Di, Xudong, et al.
Publicado: (2012)

Crosstalk between the Smad and the Mitogen-Activated Protein Kinase Pathways is Essential for Erythroid Differentiation of Erythroleukemia Cells Induced by TGF-β, Activin, Hydroxyurea and Butyrate
por: Akel, Salem, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_gfhn2fkrmd9vk6a7r4jvijn7nb