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N-Myc and GCN5 Regulate Significantly Overlapping Transcriptional Programs in Neural Stem Cells
Here we examine the functions of the Myc cofactor and histone acetyltransferase, GCN5/KAT2A, in neural stem and precursor cells (NSC) using a conditional knockout approach driven by nestin-cre. Mice with GCN5-deficient NSC exhibit a 25% reduction in brain mass with a microcephaly phenotype similar t...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383708/ https://www.ncbi.nlm.nih.gov/pubmed/22745758 http://dx.doi.org/10.1371/journal.pone.0039456 |