A diurnal rhythm in glucose uptake in brown adipose tissue revealed by in vivo PET-FDG imaging

Using a micro-PET/CT scanner, we have measured (18)F-fluorodeoxyglucose uptake in interscapular brown adipose tissue (iBAT) in C57Bl/6 mice at intervals across a 24-hour light-dark cycle. Our data reveals a strong 24-hour profile of glucose uptake of iBAT, peaking at approximately 9 hours into the l...

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Autores principales: van der Veen, Daan R, Shao, Jinping, Chapman, Sarah, Leevy, W Matthew, Duffield, Giles E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383904/
https://www.ncbi.nlm.nih.gov/pubmed/22447290
http://dx.doi.org/10.1038/oby.2012.78
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author van der Veen, Daan R
Shao, Jinping
Chapman, Sarah
Leevy, W Matthew
Duffield, Giles E
author_facet van der Veen, Daan R
Shao, Jinping
Chapman, Sarah
Leevy, W Matthew
Duffield, Giles E
author_sort van der Veen, Daan R
collection PubMed
description Using a micro-PET/CT scanner, we have measured (18)F-fluorodeoxyglucose uptake in interscapular brown adipose tissue (iBAT) in C57Bl/6 mice at intervals across a 24-hour light-dark cycle. Our data reveals a strong 24-hour profile of glucose uptake of iBAT, peaking at approximately 9 hours into the light phase of the 12 hour light, 12 hour dark day. BAT is increasingly gaining attention as being involved in metabolic phenotypes and obesity, where BAT, as observed by PET analysis, negatively correlates with obesity and age. Conversely, animals that show perturbations in circadian clocks, behavior and physiology show metabolic phenotypes. The observation of a 24-hour rhythm in glucose uptake in iBAT makes this tissue a candidate site of interaction between metabolic and circadian systems.
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spelling pubmed-33839042013-01-01 A diurnal rhythm in glucose uptake in brown adipose tissue revealed by in vivo PET-FDG imaging van der Veen, Daan R Shao, Jinping Chapman, Sarah Leevy, W Matthew Duffield, Giles E Obesity (Silver Spring) Article Using a micro-PET/CT scanner, we have measured (18)F-fluorodeoxyglucose uptake in interscapular brown adipose tissue (iBAT) in C57Bl/6 mice at intervals across a 24-hour light-dark cycle. Our data reveals a strong 24-hour profile of glucose uptake of iBAT, peaking at approximately 9 hours into the light phase of the 12 hour light, 12 hour dark day. BAT is increasingly gaining attention as being involved in metabolic phenotypes and obesity, where BAT, as observed by PET analysis, negatively correlates with obesity and age. Conversely, animals that show perturbations in circadian clocks, behavior and physiology show metabolic phenotypes. The observation of a 24-hour rhythm in glucose uptake in iBAT makes this tissue a candidate site of interaction between metabolic and circadian systems. 2012-03-26 2012-07 /pmc/articles/PMC3383904/ /pubmed/22447290 http://dx.doi.org/10.1038/oby.2012.78 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
van der Veen, Daan R
Shao, Jinping
Chapman, Sarah
Leevy, W Matthew
Duffield, Giles E
A diurnal rhythm in glucose uptake in brown adipose tissue revealed by in vivo PET-FDG imaging
title A diurnal rhythm in glucose uptake in brown adipose tissue revealed by in vivo PET-FDG imaging
title_full A diurnal rhythm in glucose uptake in brown adipose tissue revealed by in vivo PET-FDG imaging
title_fullStr A diurnal rhythm in glucose uptake in brown adipose tissue revealed by in vivo PET-FDG imaging
title_full_unstemmed A diurnal rhythm in glucose uptake in brown adipose tissue revealed by in vivo PET-FDG imaging
title_short A diurnal rhythm in glucose uptake in brown adipose tissue revealed by in vivo PET-FDG imaging
title_sort diurnal rhythm in glucose uptake in brown adipose tissue revealed by in vivo pet-fdg imaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383904/
https://www.ncbi.nlm.nih.gov/pubmed/22447290
http://dx.doi.org/10.1038/oby.2012.78
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