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Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning
In the vertebrate head, central and peripheral components of the sensory nervous system have different embryonic origins, the neural plate and sensory placodes. This raises the question of how they develop in register to form functional sense organs and sensory circuits. Here we show that mutual rep...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384001/ https://www.ncbi.nlm.nih.gov/pubmed/22564795 http://dx.doi.org/10.1016/j.ydbio.2012.04.025 |
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author | Steventon, Ben Mayor, Roberto Streit, Andrea |
author_facet | Steventon, Ben Mayor, Roberto Streit, Andrea |
author_sort | Steventon, Ben |
collection | PubMed |
description | In the vertebrate head, central and peripheral components of the sensory nervous system have different embryonic origins, the neural plate and sensory placodes. This raises the question of how they develop in register to form functional sense organs and sensory circuits. Here we show that mutual repression between the homeobox transcription factors Gbx2 and Otx2 patterns the placode territory by influencing regional identity and by segregating inner ear and trigeminal progenitors. Activation of Otx2 targets is necessary for anterior olfactory, lens and trigeminal character, while Gbx2 function is required for the formation of the posterior otic placode. Thus, like in the neural plate antagonistic interaction between Otx2 and Gbx2 establishes positional information thus providing a general mechanism for rostro-caudal patterning of the ectoderm. Our findings support the idea that the Otx/Gbx boundary has an ancient evolutionary origin to which different modules were recruited to specify cells of different fates. |
format | Online Article Text |
id | pubmed-3384001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-33840012012-07-05 Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning Steventon, Ben Mayor, Roberto Streit, Andrea Dev Biol Article In the vertebrate head, central and peripheral components of the sensory nervous system have different embryonic origins, the neural plate and sensory placodes. This raises the question of how they develop in register to form functional sense organs and sensory circuits. Here we show that mutual repression between the homeobox transcription factors Gbx2 and Otx2 patterns the placode territory by influencing regional identity and by segregating inner ear and trigeminal progenitors. Activation of Otx2 targets is necessary for anterior olfactory, lens and trigeminal character, while Gbx2 function is required for the formation of the posterior otic placode. Thus, like in the neural plate antagonistic interaction between Otx2 and Gbx2 establishes positional information thus providing a general mechanism for rostro-caudal patterning of the ectoderm. Our findings support the idea that the Otx/Gbx boundary has an ancient evolutionary origin to which different modules were recruited to specify cells of different fates. Elsevier 2012-07-01 /pmc/articles/PMC3384001/ /pubmed/22564795 http://dx.doi.org/10.1016/j.ydbio.2012.04.025 Text en © 2012 Elsevier Inc. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license |
spellingShingle | Article Steventon, Ben Mayor, Roberto Streit, Andrea Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning |
title | Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning |
title_full | Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning |
title_fullStr | Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning |
title_full_unstemmed | Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning |
title_short | Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning |
title_sort | mutual repression between gbx2 and otx2 in sensory placodes reveals a general mechanism for ectodermal patterning |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384001/ https://www.ncbi.nlm.nih.gov/pubmed/22564795 http://dx.doi.org/10.1016/j.ydbio.2012.04.025 |
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