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Crystal Structures of a Stabilized β(1)-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol

The β(1)-adrenoceptor (β(1)AR) is the site of action of beta blockers used in the treatment of cardiac-related illnesses. Two beta blockers, carvedilol and bucindolol, show distinctive activities compared to other beta blockers and have been proposed as treatments tailored to the Arg/Gly389(8.56) po...

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Detalles Bibliográficos
Autores principales:	Warne, Tony, Edwards, Patricia C., Leslie, Andrew G.W., Tate, Christopher G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384003/ https://www.ncbi.nlm.nih.gov/pubmed/22579251 http://dx.doi.org/10.1016/j.str.2012.03.014

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