Hippocampal subfields predict positive symptoms in schizophrenia: First evidence from brain morphometry

Alterations of hippocampal anatomy have been reported consistently in schizophrenia. Within the present study, we used FreeSurfer to determine hippocampal subfield volumes in 21 schizophrenic patients. A negative correlation between PANSS-positive symptom score and bilateral hippocampal subfield CA2...

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Autores principales: Kühn, S, Musso, F, Mobascher, A, Warbrick, T, Winterer, G, Gallinat, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384220/
https://www.ncbi.nlm.nih.gov/pubmed/22692142
http://dx.doi.org/10.1038/tp.2012.51
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author Kühn, S
Musso, F
Mobascher, A
Warbrick, T
Winterer, G
Gallinat, J
author_facet Kühn, S
Musso, F
Mobascher, A
Warbrick, T
Winterer, G
Gallinat, J
author_sort Kühn, S
collection PubMed
description Alterations of hippocampal anatomy have been reported consistently in schizophrenia. Within the present study, we used FreeSurfer to determine hippocampal subfield volumes in 21 schizophrenic patients. A negative correlation between PANSS-positive symptom score and bilateral hippocampal subfield CA2/3 as well as CA1 volume was found on high-resolution magnetic resonance images. Our observation opens the gate for advanced investigation of the commonly reported hippocampal abnormalities in schizophrenia in terms of specific subfields.
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spelling pubmed-33842202012-06-27 Hippocampal subfields predict positive symptoms in schizophrenia: First evidence from brain morphometry Kühn, S Musso, F Mobascher, A Warbrick, T Winterer, G Gallinat, J Transl Psychiatry Original Article Alterations of hippocampal anatomy have been reported consistently in schizophrenia. Within the present study, we used FreeSurfer to determine hippocampal subfield volumes in 21 schizophrenic patients. A negative correlation between PANSS-positive symptom score and bilateral hippocampal subfield CA2/3 as well as CA1 volume was found on high-resolution magnetic resonance images. Our observation opens the gate for advanced investigation of the commonly reported hippocampal abnormalities in schizophrenia in terms of specific subfields. Nature Publishing Group 2012-06 2012-06-12 /pmc/articles/PMC3384220/ /pubmed/22692142 http://dx.doi.org/10.1038/tp.2012.51 Text en Copyright © 2012 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Original Article
Kühn, S
Musso, F
Mobascher, A
Warbrick, T
Winterer, G
Gallinat, J
Hippocampal subfields predict positive symptoms in schizophrenia: First evidence from brain morphometry
title Hippocampal subfields predict positive symptoms in schizophrenia: First evidence from brain morphometry
title_full Hippocampal subfields predict positive symptoms in schizophrenia: First evidence from brain morphometry
title_fullStr Hippocampal subfields predict positive symptoms in schizophrenia: First evidence from brain morphometry
title_full_unstemmed Hippocampal subfields predict positive symptoms in schizophrenia: First evidence from brain morphometry
title_short Hippocampal subfields predict positive symptoms in schizophrenia: First evidence from brain morphometry
title_sort hippocampal subfields predict positive symptoms in schizophrenia: first evidence from brain morphometry
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384220/
https://www.ncbi.nlm.nih.gov/pubmed/22692142
http://dx.doi.org/10.1038/tp.2012.51
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