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Single-molecule multiparameter fluorescence spectroscopy reveals directional MutS binding to mismatched bases in DNA

Mismatch repair (MMR) corrects replication errors such as mismatched bases and loops in DNA. The evolutionarily conserved dimeric MMR protein MutS recognizes mismatches by stacking a phenylalanine of one subunit against one base of the mismatched pair. In all crystal structures of G:T mismatch-bound...

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Detalles Bibliográficos
Autores principales:	Cristóvão, Michele, Sisamakis, Evangelos, Hingorani, Manju M., Marx, Andreas D., Jung, Caroline P., Rothwell, Paul J., Seidel, Claus A. M., Friedhoff, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384296/ https://www.ncbi.nlm.nih.gov/pubmed/22367846 http://dx.doi.org/10.1093/nar/gks138

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