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Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases λ and β on normal and repetitive DNA sequences

‘Classical’ non-homologous end joining (NHEJ), dependent on the Ku70/80 and the DNA ligase IV/XRCC4 complexes, is essential for the repair of DNA double-strand breaks. Eukaryotic cells possess also an alternative microhomology-mediated end-joining (MMEJ) mechanism, which is independent from Ku and D...

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Detalles Bibliográficos
Autores principales:	Crespan, Emmanuele, Czabany, Tibor, Maga, Giovanni, Hübscher, Ulrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384310/ https://www.ncbi.nlm.nih.gov/pubmed/22373917 http://dx.doi.org/10.1093/nar/gks186

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