The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation

The ARF tumour suppressor stabilizes p53 by negatively regulating the E3 ubiquitin ligase MDM2 to promote cell cycle arrest and cell death. However, ARF is also able to arrest cell proliferation by inhibiting ribosome biogenesis. In greater part this is achieved by targeting the transcription termin...

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Detalles Bibliográficos
Autores principales: Lessard, Frédéric, Stefanovsky, Victor, Tremblay, Michel G., Moss, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384320/
https://www.ncbi.nlm.nih.gov/pubmed/22383580
http://dx.doi.org/10.1093/nar/gks198

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