Intracellular stability of 2′-OMe-4′-thioribonucleoside modified siRNA leads to long-term RNAi effect

Chemically modified siRNAs are expected to have resistance toward nuclease degradation and good thermal stability in duplex formation for in vivo applications. We have recently found that 2′-OMe-4′-thioRNA, a hybrid chemical modification based on 2′-OMeRNA and 4′-thioRNA, has high hybridization affi...

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Detalles Bibliográficos
Autores principales: Takahashi, Mayumi, Nagai, Chisato, Hatakeyama, Hiroto, Minakawa, Noriaki, Harashima, Hideyoshi, Matsuda, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Synthetic Biology and Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384325/
https://www.ncbi.nlm.nih.gov/pubmed/22411910
http://dx.doi.org/10.1093/nar/gks204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384325/
https://www.ncbi.nlm.nih.gov/pubmed/22411910
http://dx.doi.org/10.1093/nar/gks204

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