Air2p is critical for the assembly and RNA-binding of the TRAMP complex and the KOW domain of Mtr4p is crucial for exosome activation

Trf4/5p-Air1/2p-Mtr4p polyadenylation complex (TRAMP) is an essential component of nuclear RNA surveillance in yeast. It recognizes a variety of nuclear transcripts produced by all three RNA polymerases, adds short poly(A) tails to aberrant or unstable RNAs and activates the exosome for their degrad...

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Detalles Bibliográficos
Autores principales: Holub, Peter, Lalakova, Jana, Cerna, Hana, Pasulka, Josef, Sarazova, Marie, Hrazdilova, Kristyna, Arce, Maria Sanudo, Hobor, Fruzsina, Stefl, Richard, Vanacova, Stepanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384339/
https://www.ncbi.nlm.nih.gov/pubmed/22402490
http://dx.doi.org/10.1093/nar/gks223

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