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CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation

To prevent accumulation of mutations, cells respond to DNA lesions by blocking cell cycle progression and initiating DNA repair. Homology-directed repair of DNA breaks requires CtIP-dependent resection of the DNA ends, which is thought to play a key role in activation of ATR (ataxia telangiectasia m...

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Detalles Bibliográficos
Autores principales:	Kousholt, Arne Nedergaard, Fugger, Kasper, Hoffmann, Saskia, Larsen, Brian D., Menzel, Tobias, Sartori, Alessandro A., Sørensen, Claus Storgaard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384414/ https://www.ncbi.nlm.nih.gov/pubmed/22733999 http://dx.doi.org/10.1083/jcb.201111065

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