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Pedigree analysis of Czech Holstein calves with schistosoma reflexum

BACKGROUND: Schistosoma reflexum (SR) is congenital syndrome briefly characterized by visceral eventration, severe dorsoflexion and ankylosis of the spine and arthrogryposis. A genetic etiology has been proposed, but conclusive evidence has not yet been provided. METHODS: Pedigree analysis was carri...

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Autor principal: Citek, Jindrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384465/
https://www.ncbi.nlm.nih.gov/pubmed/22472123
http://dx.doi.org/10.1186/1751-0147-54-22
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author Citek, Jindrich
author_facet Citek, Jindrich
author_sort Citek, Jindrich
collection PubMed
description BACKGROUND: Schistosoma reflexum (SR) is congenital syndrome briefly characterized by visceral eventration, severe dorsoflexion and ankylosis of the spine and arthrogryposis. A genetic etiology has been proposed, but conclusive evidence has not yet been provided. METHODS: Pedigree analysis was carried out in 29 cases of SR in Czech Holsteins and Holstein crosses. Genetic relationship was evaluated and inbreeding coefficients calculated. Pedigrees of 15 Czech Holsteins fathering non-SR affected calves were used for comparison. RESULTS: Twenty-one cases occurred in one pedigree founded by three sires while three SR calves occurred in another pedigree with a common grandfather. The sex ratio between affected males and females was 11:6. Affected calves shared common ancestors different from those shared by the unaffected calves. The inbreeding coefficient in the SR affected calves was not increased compared to unaffected calves. CONCLUSIONS: The findings are consistent with SR being inherited autosomal recessively. Further studies are however needed to confirm this and therefore a breeding trial is recommended where a suspected heterozygous sire is mated to closely related females.
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spelling pubmed-33844652012-06-29 Pedigree analysis of Czech Holstein calves with schistosoma reflexum Citek, Jindrich Acta Vet Scand Research BACKGROUND: Schistosoma reflexum (SR) is congenital syndrome briefly characterized by visceral eventration, severe dorsoflexion and ankylosis of the spine and arthrogryposis. A genetic etiology has been proposed, but conclusive evidence has not yet been provided. METHODS: Pedigree analysis was carried out in 29 cases of SR in Czech Holsteins and Holstein crosses. Genetic relationship was evaluated and inbreeding coefficients calculated. Pedigrees of 15 Czech Holsteins fathering non-SR affected calves were used for comparison. RESULTS: Twenty-one cases occurred in one pedigree founded by three sires while three SR calves occurred in another pedigree with a common grandfather. The sex ratio between affected males and females was 11:6. Affected calves shared common ancestors different from those shared by the unaffected calves. The inbreeding coefficient in the SR affected calves was not increased compared to unaffected calves. CONCLUSIONS: The findings are consistent with SR being inherited autosomal recessively. Further studies are however needed to confirm this and therefore a breeding trial is recommended where a suspected heterozygous sire is mated to closely related females. BioMed Central 2012-04-02 /pmc/articles/PMC3384465/ /pubmed/22472123 http://dx.doi.org/10.1186/1751-0147-54-22 Text en Copyright ©2012 Citek; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Citek, Jindrich
Pedigree analysis of Czech Holstein calves with schistosoma reflexum
title Pedigree analysis of Czech Holstein calves with schistosoma reflexum
title_full Pedigree analysis of Czech Holstein calves with schistosoma reflexum
title_fullStr Pedigree analysis of Czech Holstein calves with schistosoma reflexum
title_full_unstemmed Pedigree analysis of Czech Holstein calves with schistosoma reflexum
title_short Pedigree analysis of Czech Holstein calves with schistosoma reflexum
title_sort pedigree analysis of czech holstein calves with schistosoma reflexum
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384465/
https://www.ncbi.nlm.nih.gov/pubmed/22472123
http://dx.doi.org/10.1186/1751-0147-54-22
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