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Evolution of the let-7 microRNA Family

The increase of bodyplan complexity in early bilaterian evolution is correlates with the advent and diversification of microRNAs. These small RNAs guide animal development by regulating temporal transitions in gene expression involved in cell fate choices and transitions between pluripotency and dif...

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Autores principales: Hertel, Jana, Bartschat, Sebastian, Wintsche, Axel, Otto, Christian, of the Bioinformatics Computer Lab, The Students, Stadler, Peter F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384580/
https://www.ncbi.nlm.nih.gov/pubmed/22617875
http://dx.doi.org/10.4161/rna.18974
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author Hertel, Jana
Bartschat, Sebastian
Wintsche, Axel
Otto, Christian
of the Bioinformatics Computer Lab, The Students
Stadler, Peter F.
author_facet Hertel, Jana
Bartschat, Sebastian
Wintsche, Axel
Otto, Christian
of the Bioinformatics Computer Lab, The Students
Stadler, Peter F.
author_sort Hertel, Jana
collection PubMed
description The increase of bodyplan complexity in early bilaterian evolution is correlates with the advent and diversification of microRNAs. These small RNAs guide animal development by regulating temporal transitions in gene expression involved in cell fate choices and transitions between pluripotency and differentiation. One of the two known microRNAs whose origins date back before the bilaterian ancestor is mir-100. In Bilateria, it appears stably associated in polycistronic transcripts with let-7 and mir-125, two key regulators of development. In vertebrates, these three microRNA families have expanded to form a complex system of developmental regulators. In this contribution, we disentangle the evolutionary history of the let-7 locus, which was restructured independently in nematodes, platyhelminths, and deuterostomes. The foundation of a second let-7 locus in the common ancestor of vertebrates and urochordates predates the vertebrate-specific genome duplications, which then caused a rapid expansion of the let-7 family.
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spelling pubmed-33845802012-06-28 Evolution of the let-7 microRNA Family Hertel, Jana Bartschat, Sebastian Wintsche, Axel Otto, Christian of the Bioinformatics Computer Lab, The Students Stadler, Peter F. RNA Biol RNA Families The increase of bodyplan complexity in early bilaterian evolution is correlates with the advent and diversification of microRNAs. These small RNAs guide animal development by regulating temporal transitions in gene expression involved in cell fate choices and transitions between pluripotency and differentiation. One of the two known microRNAs whose origins date back before the bilaterian ancestor is mir-100. In Bilateria, it appears stably associated in polycistronic transcripts with let-7 and mir-125, two key regulators of development. In vertebrates, these three microRNA families have expanded to form a complex system of developmental regulators. In this contribution, we disentangle the evolutionary history of the let-7 locus, which was restructured independently in nematodes, platyhelminths, and deuterostomes. The foundation of a second let-7 locus in the common ancestor of vertebrates and urochordates predates the vertebrate-specific genome duplications, which then caused a rapid expansion of the let-7 family. Landes Bioscience 2012-03-01 /pmc/articles/PMC3384580/ /pubmed/22617875 http://dx.doi.org/10.4161/rna.18974 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle RNA Families
Hertel, Jana
Bartschat, Sebastian
Wintsche, Axel
Otto, Christian
of the Bioinformatics Computer Lab, The Students
Stadler, Peter F.
Evolution of the let-7 microRNA Family
title Evolution of the let-7 microRNA Family
title_full Evolution of the let-7 microRNA Family
title_fullStr Evolution of the let-7 microRNA Family
title_full_unstemmed Evolution of the let-7 microRNA Family
title_short Evolution of the let-7 microRNA Family
title_sort evolution of the let-7 microrna family
topic RNA Families
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384580/
https://www.ncbi.nlm.nih.gov/pubmed/22617875
http://dx.doi.org/10.4161/rna.18974
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