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Deletion of the BDNF Truncated Receptor TrkB.T1 Delays Disease Onset in a Mouse Model of Amyotrophic Lateral Sclerosis

Brain Derived Neurotrophic Factor (BDNF) exerts strong pro-survival effects on developing and injured motoneurons. However, in clinical trials, BDNF has failed to benefit patients with amyotrophic lateral sclerosis (ALS). To date, the cause of this failure remains unclear. Motoneurons express the Tr...

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Detalles Bibliográficos
Autores principales:	Yanpallewar, Sudhirkumar U., Barrick, Colleen A., Buckley, Hannah, Becker, Jodi, Tessarollo, Lino
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384607/ https://www.ncbi.nlm.nih.gov/pubmed/22761934 http://dx.doi.org/10.1371/journal.pone.0039946

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