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MYC Rearrangement Involving a Novel Non-immunoglobulin Chromosomal Locus in Precursor B-cell Acute Lymphoblastic Leukemia
MYC rearrangement, a characteristic cytogenetic abnormality of Burkitt lymphoma and several subsets of other mature B-cell neoplasms, typically involves an immunoglobulin gene partner. Herein, we describe a case of precursor B-cell lymphoblastic leukemia harboring a MYC rearrangement with a novel no...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society for Laboratory Medicine
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384811/ https://www.ncbi.nlm.nih.gov/pubmed/22779071 http://dx.doi.org/10.3343/alm.2012.32.4.289 |
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author | Seo, Ja-Young Lee, Soo Hyun Kim, Hee-Jin Yoo, Keon Hee Koo, Hong Hoe Cho, Yong Gon Choi, Sam Im Kim, Sun-Hee |
author_facet | Seo, Ja-Young Lee, Soo Hyun Kim, Hee-Jin Yoo, Keon Hee Koo, Hong Hoe Cho, Yong Gon Choi, Sam Im Kim, Sun-Hee |
author_sort | Seo, Ja-Young |
collection | PubMed |
description | MYC rearrangement, a characteristic cytogenetic abnormality of Burkitt lymphoma and several subsets of other mature B-cell neoplasms, typically involves an immunoglobulin gene partner. Herein, we describe a case of precursor B-cell lymphoblastic leukemia harboring a MYC rearrangement with a novel non-immunoglobulin partner locus. The patient was a 4-yr-old Korean boy with ALL of the precursor B-cell immunophenotype. At the time of the second relapse, cytogenetic analyses revealed t(4;8)(q31.1;q24.1) as a clonal evolution. The MYC rearrangement was confirmed by FISH analysis. He died 3 months after the second relapse without achieving complete remission. To our knowledge, this is the first report of a case of MYC rearrangement with a non-immunoglobulin partner in precursor B-cell lymphoblastic leukemia. |
format | Online Article Text |
id | pubmed-3384811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Society for Laboratory Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-33848112012-07-10 MYC Rearrangement Involving a Novel Non-immunoglobulin Chromosomal Locus in Precursor B-cell Acute Lymphoblastic Leukemia Seo, Ja-Young Lee, Soo Hyun Kim, Hee-Jin Yoo, Keon Hee Koo, Hong Hoe Cho, Yong Gon Choi, Sam Im Kim, Sun-Hee Ann Lab Med Case Report MYC rearrangement, a characteristic cytogenetic abnormality of Burkitt lymphoma and several subsets of other mature B-cell neoplasms, typically involves an immunoglobulin gene partner. Herein, we describe a case of precursor B-cell lymphoblastic leukemia harboring a MYC rearrangement with a novel non-immunoglobulin partner locus. The patient was a 4-yr-old Korean boy with ALL of the precursor B-cell immunophenotype. At the time of the second relapse, cytogenetic analyses revealed t(4;8)(q31.1;q24.1) as a clonal evolution. The MYC rearrangement was confirmed by FISH analysis. He died 3 months after the second relapse without achieving complete remission. To our knowledge, this is the first report of a case of MYC rearrangement with a non-immunoglobulin partner in precursor B-cell lymphoblastic leukemia. The Korean Society for Laboratory Medicine 2012-07 2012-06-20 /pmc/articles/PMC3384811/ /pubmed/22779071 http://dx.doi.org/10.3343/alm.2012.32.4.289 Text en © The Korean Society for Laboratory Medicine. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Seo, Ja-Young Lee, Soo Hyun Kim, Hee-Jin Yoo, Keon Hee Koo, Hong Hoe Cho, Yong Gon Choi, Sam Im Kim, Sun-Hee MYC Rearrangement Involving a Novel Non-immunoglobulin Chromosomal Locus in Precursor B-cell Acute Lymphoblastic Leukemia |
title | MYC Rearrangement Involving a Novel Non-immunoglobulin Chromosomal Locus in Precursor B-cell Acute Lymphoblastic Leukemia |
title_full | MYC Rearrangement Involving a Novel Non-immunoglobulin Chromosomal Locus in Precursor B-cell Acute Lymphoblastic Leukemia |
title_fullStr | MYC Rearrangement Involving a Novel Non-immunoglobulin Chromosomal Locus in Precursor B-cell Acute Lymphoblastic Leukemia |
title_full_unstemmed | MYC Rearrangement Involving a Novel Non-immunoglobulin Chromosomal Locus in Precursor B-cell Acute Lymphoblastic Leukemia |
title_short | MYC Rearrangement Involving a Novel Non-immunoglobulin Chromosomal Locus in Precursor B-cell Acute Lymphoblastic Leukemia |
title_sort | myc rearrangement involving a novel non-immunoglobulin chromosomal locus in precursor b-cell acute lymphoblastic leukemia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384811/ https://www.ncbi.nlm.nih.gov/pubmed/22779071 http://dx.doi.org/10.3343/alm.2012.32.4.289 |
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