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Methotrexate Increases Skeletal Muscle GLUT4 Expression and Improves Metabolic Control in Experimental Diabetes

Long-term administration of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) mimics the effects of endurance exercise by activating AMP kinase and by increasing skeletal muscle expression of GLUT4 glucose transporter. AICAR is an intermediate in the purine de novo synthesis, and its tissue conc...

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Detalles Bibliográficos
Autores principales:	Russo, Giuseppina T., Minutoli, Letteria, Bitto, Alessandra, Altavilla, Domenica, Alessi, Eugenio, Giandalia, Annalisa, Romeo, Elisabetta L., Stagno, Maria Francesca, Squadrito, Francesco, Cucinotta, Domenico, Selhub, Jacob
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384889/ https://www.ncbi.nlm.nih.gov/pubmed/22778921 http://dx.doi.org/10.1155/2012/132056

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