Glycogen Synthase Kinase 3: A Point of Integration in Alzheimer's Disease and a Therapeutic Target?

Glycogen synthase kinase 3 (GSK3) has been implicated in neurological disorders; therefore, it is not surprising that there has been an increased focus towards developing therapies directed to this kinase. Unfortunately, these current therapies have not taken into consideration the physiological rol...

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Autores principales: Mondragón-Rodríguez, Siddhartha, Perry, George, Zhu, Xiongwei, Moreira, Paula I., Williams, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384908/
https://www.ncbi.nlm.nih.gov/pubmed/22779025
http://dx.doi.org/10.1155/2012/276803
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author Mondragón-Rodríguez, Siddhartha
Perry, George
Zhu, Xiongwei
Moreira, Paula I.
Williams, Sylvain
author_facet Mondragón-Rodríguez, Siddhartha
Perry, George
Zhu, Xiongwei
Moreira, Paula I.
Williams, Sylvain
author_sort Mondragón-Rodríguez, Siddhartha
collection PubMed
description Glycogen synthase kinase 3 (GSK3) has been implicated in neurological disorders; therefore, it is not surprising that there has been an increased focus towards developing therapies directed to this kinase. Unfortunately, these current therapies have not taken into consideration the physiological role of GSK3 in crucial events like synaptic plasticity. With this in mind we will discuss the relationship of synaptic plasticity with GSK3 and tau protein and their role as potential targets for the development of therapeutic strategies. Finally, we will provide perspectives in developing a cocktail therapy for Alzheimer's treatment.
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spelling pubmed-33849082012-07-09 Glycogen Synthase Kinase 3: A Point of Integration in Alzheimer's Disease and a Therapeutic Target? Mondragón-Rodríguez, Siddhartha Perry, George Zhu, Xiongwei Moreira, Paula I. Williams, Sylvain Int J Alzheimers Dis Review Article Glycogen synthase kinase 3 (GSK3) has been implicated in neurological disorders; therefore, it is not surprising that there has been an increased focus towards developing therapies directed to this kinase. Unfortunately, these current therapies have not taken into consideration the physiological role of GSK3 in crucial events like synaptic plasticity. With this in mind we will discuss the relationship of synaptic plasticity with GSK3 and tau protein and their role as potential targets for the development of therapeutic strategies. Finally, we will provide perspectives in developing a cocktail therapy for Alzheimer's treatment. Hindawi Publishing Corporation 2012 2012-06-14 /pmc/articles/PMC3384908/ /pubmed/22779025 http://dx.doi.org/10.1155/2012/276803 Text en Copyright © 2012 Siddhartha Mondragón-Rodríguez et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mondragón-Rodríguez, Siddhartha
Perry, George
Zhu, Xiongwei
Moreira, Paula I.
Williams, Sylvain
Glycogen Synthase Kinase 3: A Point of Integration in Alzheimer's Disease and a Therapeutic Target?
title Glycogen Synthase Kinase 3: A Point of Integration in Alzheimer's Disease and a Therapeutic Target?
title_full Glycogen Synthase Kinase 3: A Point of Integration in Alzheimer's Disease and a Therapeutic Target?
title_fullStr Glycogen Synthase Kinase 3: A Point of Integration in Alzheimer's Disease and a Therapeutic Target?
title_full_unstemmed Glycogen Synthase Kinase 3: A Point of Integration in Alzheimer's Disease and a Therapeutic Target?
title_short Glycogen Synthase Kinase 3: A Point of Integration in Alzheimer's Disease and a Therapeutic Target?
title_sort glycogen synthase kinase 3: a point of integration in alzheimer's disease and a therapeutic target?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384908/
https://www.ncbi.nlm.nih.gov/pubmed/22779025
http://dx.doi.org/10.1155/2012/276803
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