Cargando…

Induction of Fetal Hemoglobin In Vivo Mediated by a Synthetic γ-Globin Zinc Finger Activator

Sickle cell disease (SCD) and β-thalassemia patients are phenotypically normal if they carry compensatory hereditary persistence of fetal hemoglobin (HPFH) mutations that result in increased levels of fetal hemoglobin (HbF, γ-globin chains) in adulthood. Thus, research has focused on manipulating th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Costa, Flávia C., Fedosyuk, Halyna, Neades, Renee, de Los Rios, Johana Bravo, Barbas, Carlos F., Peterson, Kenneth R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384929/ https://www.ncbi.nlm.nih.gov/pubmed/22778925 http://dx.doi.org/10.1155/2012/507894

Ejemplares similares

Mi2β Is Required for γ-Globin Gene Silencing: Temporal Assembly of a GATA-1-FOG-1-Mi2 Repressor Complex in β-YAC Transgenic Mice
por: Costa, Flávia C., et al.
Publicado: (2012)

A Cell-Based High-Throughput Screen for Novel Chemical Inducers of Fetal Hemoglobin for Treatment of Hemoglobinopathies
por: Peterson, Kenneth R., et al.
Publicado: (2014)

LCR 5′ hypersensitive site specificity for globin gene activation within the active chromatin hub
por: Peterson, Kenneth R., et al.
Publicado: (2012)

Episomal vectors based on S/MAR and the β-globin Replicator, encoding a synthetic transcriptional activator, mediate efficient γ-globin activation in haematopoietic cells
por: Stavrou, Eleana F., et al.
Publicado: (2019)

An Aγ-globin G->A gene polymorphism associated with β(0)39 thalassemia globin gene and high fetal hemoglobin production
por: Breveglieri, Giulia, et al.
Publicado: (2017)

Induction of Fetal Hemoglobin by Introducing Natural Hereditary Persistence of Fetal Hemoglobin Mutations in the γ-Globin Gene Promoters for Genome Editing Therapies for β-Thalassemia
por: Lu, Dian, et al.
Publicado: (2022)

Evaluation of Signaling Pathways Involved in γ-Globin Gene Induction Using Fetal Hemoglobin Inducer Drugs
por: Rahim, Fakher, et al.
Publicado: (2013)

Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin
por: Doerfler, Phillip A., et al.
Publicado: (2021)

Trienone analogs of curcuminoids induce fetal hemoglobin synthesis via demethylation at (G)γ-globin gene promoter
por: Nuamsee, Khanita, et al.
Publicado: (2021)

Transcription factor competition at the γ-globin promoters controls hemoglobin switching
por: Liu, Nan, et al.
Publicado: (2021)

Base-editing-mediated dissection of a γ-globin cis-regulatory element for the therapeutic reactivation of fetal hemoglobin expression
por: Antoniou, Panagiotis, et al.
Publicado: (2022)

Editing a γ-globin repressor binding site restores fetal hemoglobin synthesis and corrects the sickle cell disease phenotype
por: Weber, Leslie, et al.
Publicado: (2020)

Synthetic Zinc Finger Proteins: The Advent of Targeted Gene Regulation and Genome Modification Technologies
por: Gersbach, Charles A., et al.
Publicado: (2014)

Positive selection of DNA-protein interactions in mammalian cells through phenotypic coupling with retrovirus production
por: Tschulena, Ulrich, et al.
Publicado: (2009)

Prevention of Transcriptional γ-globin Gene Silencing by Inducing The Hereditary Persistence of Fetal Hemoglobin Point Mutation Using Chimeraplast-Mediated Gene Targeting
por: Ranjbaran, Reza, et al.
Publicado: (2018)

Genetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian population
por: Fong, Cristian, et al.
Publicado: (2020)

GLOBIN UTILIZATION BY THE ANEMIC DOG TO FORM NEW HEMOGLOBIN
por: Robscheit-Robbins, F. S., et al.
Publicado: (1937)

Analysis of deletional hereditary persistence of fetal hemoglobin/δβ‐thalassemia and δ‐globin gene mutations in Southerwestern China
por: Zhang, Jie, et al.
Publicado: (2019)

3′HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression
por: Himadewi, Pamela, et al.
Publicado: (2021)

Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling
por: De Souza, Daniel C., et al.
Publicado: (2023)

Rapid isolation of yeast genomic DNA: Bust n' Grab
por: Harju, Susanna, et al.
Publicado: (2004)

Dissecting the function of the adult β-globin downstream promoter region using an artificial zinc finger DNA-binding domain
por: Barrow, Joeva J., et al.
Publicado: (2014)

Reciprocal regulation of γ-globin expression by exo-miRNAs: Relevance to γ-globin silencing in β-thalassemia major
por: Sun, Kuo-Ting, et al.
Publicado: (2017)

Correlation of BACH1 and Hemoglobin E/Beta-Thalassemia Globin Expression
por: Lee, Tze Yan, et al.
Publicado: (2016)

Migration of small ligands in globins: Xe diffusion in truncated hemoglobin N
por: Diamantis, Polydefkis, et al.
Publicado: (2017)

Zinc Finger Tools: custom DNA-binding domains for transcription factors and nucleases
por: Mandell, Jeffrey G., et al.
Publicado: (2006)

Human fetal globin gene expression is regulated by LYAR
por: Ju, Junyi, et al.
Publicado: (2014)

Physiological and Aberrant γ-Globin Transcription During Development
por: Barbarani, Gloria, et al.
Publicado: (2021)

The methyltransferase PRMT1 regulates γ-globin translation
por: Wang, Ying, et al.
Publicado: (2021)

Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts
por: Vinjamur, Divya S., et al.
Publicado: (2016)

Design of a Zinc-Finger Hydrolase with a Synthetic αββ Protein
por: Srivastava, Kinshuk Raj, et al.
Publicado: (2014)

Modular Synthetic Inverters from Zinc Finger Proteins and Small RNAs
por: Hsia, Justin, et al.
Publicado: (2016)

The zinc finger domain of IKKγ (NEMO) protein in health and disease
por: Shifera, Amde Selassie
Publicado: (2010)

Mutations in the paralogous human α-globin genes yielding identical hemoglobin variants
por: Moradkhani, Kamran, et al.
Publicado: (2008)

More than hemoglobin – the unexpected diversity of globins in vertebrate red blood cells
por: Götting, Miriam, et al.
Publicado: (2015)

Improved Cell-Penetrating Zinc-Finger Nuclease Proteins for Precision Genome Engineering
por: Liu, Jia, et al.
Publicado: (2015)

Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase
por: Gersbach, Charles A., et al.
Publicado: (2011)

P1460: INDUCTION OF FETAL HEMOGLOBIN BY TARGETED DELETION OF ZINC FINGER DOMAIN WITHIN BCL11A GENE USING CRISPR-CAS9 TECHNOLOGY
por: Hussain, Irfan, et al.
Publicado: (2023)

The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes
por: Woon Kim, Yea, et al.
Publicado: (2011)

Association of Xmn I Polymorphism and Hemoglobin E Haplotypes on Postnatal Gamma Globin Gene Expression in Homozygous Hemoglobin E
por: Ekwattanakit, Supachai, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_l95oj1l0dt653u9kvff8jpul1d