Serum CA19-9 Level Associated with Metabolic Control and Pancreatic Beta Cell Function in Diabetic Patients

CA19-9 is a tumor-associated antigen. It is also a marker of pancreatic tissue damage that might be caused by diabetes. Long-term poor glycemic control may lead to pancreatic beta cell dysfunction which is reflected by elevated serum CA19-9 level. Intracellular cholesterol accumulation leads to isle...

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Detalles Bibliográficos
Autores principales: Yu, Haoyong, Li, Ruixia, Zhang, Lei, Chen, Haibing, Bao, Yuqian, Jia, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384953/
https://www.ncbi.nlm.nih.gov/pubmed/22778715
http://dx.doi.org/10.1155/2012/745189
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author Yu, Haoyong
Li, Ruixia
Zhang, Lei
Chen, Haibing
Bao, Yuqian
Jia, Weiping
author_facet Yu, Haoyong
Li, Ruixia
Zhang, Lei
Chen, Haibing
Bao, Yuqian
Jia, Weiping
author_sort Yu, Haoyong
collection PubMed
description CA19-9 is a tumor-associated antigen. It is also a marker of pancreatic tissue damage that might be caused by diabetes. Long-term poor glycemic control may lead to pancreatic beta cell dysfunction which is reflected by elevated serum CA19-9 level. Intracellular cholesterol accumulation leads to islet dysfunction and impaired insulin secretion which provide a new lipotoxic model. This study firstly found total cholesterol was one of the independent contributors to CA19-9. Elevated serum CA19-9 level in diabetic patients may indicate further investigations of glycemic control, pancreatic beta cell function, and total cholesterol level.
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spelling pubmed-33849532012-07-09 Serum CA19-9 Level Associated with Metabolic Control and Pancreatic Beta Cell Function in Diabetic Patients Yu, Haoyong Li, Ruixia Zhang, Lei Chen, Haibing Bao, Yuqian Jia, Weiping Exp Diabetes Res Clinical Study CA19-9 is a tumor-associated antigen. It is also a marker of pancreatic tissue damage that might be caused by diabetes. Long-term poor glycemic control may lead to pancreatic beta cell dysfunction which is reflected by elevated serum CA19-9 level. Intracellular cholesterol accumulation leads to islet dysfunction and impaired insulin secretion which provide a new lipotoxic model. This study firstly found total cholesterol was one of the independent contributors to CA19-9. Elevated serum CA19-9 level in diabetic patients may indicate further investigations of glycemic control, pancreatic beta cell function, and total cholesterol level. Hindawi Publishing Corporation 2012 2012-06-12 /pmc/articles/PMC3384953/ /pubmed/22778715 http://dx.doi.org/10.1155/2012/745189 Text en Copyright © 2012 Haoyong Yu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Yu, Haoyong
Li, Ruixia
Zhang, Lei
Chen, Haibing
Bao, Yuqian
Jia, Weiping
Serum CA19-9 Level Associated with Metabolic Control and Pancreatic Beta Cell Function in Diabetic Patients
title Serum CA19-9 Level Associated with Metabolic Control and Pancreatic Beta Cell Function in Diabetic Patients
title_full Serum CA19-9 Level Associated with Metabolic Control and Pancreatic Beta Cell Function in Diabetic Patients
title_fullStr Serum CA19-9 Level Associated with Metabolic Control and Pancreatic Beta Cell Function in Diabetic Patients
title_full_unstemmed Serum CA19-9 Level Associated with Metabolic Control and Pancreatic Beta Cell Function in Diabetic Patients
title_short Serum CA19-9 Level Associated with Metabolic Control and Pancreatic Beta Cell Function in Diabetic Patients
title_sort serum ca19-9 level associated with metabolic control and pancreatic beta cell function in diabetic patients
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384953/
https://www.ncbi.nlm.nih.gov/pubmed/22778715
http://dx.doi.org/10.1155/2012/745189
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