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Inhibitory Monoclonal Antibodies against Mouse Proteases Raised in Gene-Deficient Mice Block Proteolytic Functions in vivo

Identification of targets for cancer therapy requires the understanding of the in vivo roles of proteins, which can be derived from studies using gene-targeted mice. An alternative strategy is the administration of inhibitory monoclonal antibodies (mAbs), causing acute disruption of the target prote...

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Detalles Bibliográficos
Autores principales:	Lund, Ida K., Rasch, Morten G., Ingvarsen, Signe, Pass, Jesper, Madsen, Daniel H., Engelholm, Lars H., Behrendt, Niels, Høyer-Hansen, Gunilla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2012
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384954/ https://www.ncbi.nlm.nih.gov/pubmed/22754528 http://dx.doi.org/10.3389/fphar.2012.00122

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