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The Role of Fragile Sites in Sporadic Papillary Thyroid Carcinoma
The incidence of thyroid cancer is increasing, especially papillary thyroid carcinoma (PTC), making it currently the fastest-growing cancer among women. Reasons for this increase remain unclear, but several risk factors including radiation exposure and improved detection techniques have been suggest...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384961/ https://www.ncbi.nlm.nih.gov/pubmed/22762011 http://dx.doi.org/10.1155/2012/927683 |
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author | Dillon, Laura W. Lehman, Christine E. Wang, Yuh-Hwa |
author_facet | Dillon, Laura W. Lehman, Christine E. Wang, Yuh-Hwa |
author_sort | Dillon, Laura W. |
collection | PubMed |
description | The incidence of thyroid cancer is increasing, especially papillary thyroid carcinoma (PTC), making it currently the fastest-growing cancer among women. Reasons for this increase remain unclear, but several risk factors including radiation exposure and improved detection techniques have been suggested. Recently, the induction of chromosomal fragile site breakage was found to result in the formation of RET/PTC1 rearrangements, a common cause of PTC. Chromosomal fragile sites are regions of the genome with a high susceptibility to forming DNA breaks and are often associated with cancer. Exposure to a variety of external agents can induce fragile site breakage, which may account for some of the observed increase in PTC. This paper discusses the role of fragile site breakage in PTC development, external fragile site-inducing agents that may be potential risk factors for PTC, and how these factors are especially targeting women. |
format | Online Article Text |
id | pubmed-3384961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33849612012-07-03 The Role of Fragile Sites in Sporadic Papillary Thyroid Carcinoma Dillon, Laura W. Lehman, Christine E. Wang, Yuh-Hwa J Thyroid Res Review Article The incidence of thyroid cancer is increasing, especially papillary thyroid carcinoma (PTC), making it currently the fastest-growing cancer among women. Reasons for this increase remain unclear, but several risk factors including radiation exposure and improved detection techniques have been suggested. Recently, the induction of chromosomal fragile site breakage was found to result in the formation of RET/PTC1 rearrangements, a common cause of PTC. Chromosomal fragile sites are regions of the genome with a high susceptibility to forming DNA breaks and are often associated with cancer. Exposure to a variety of external agents can induce fragile site breakage, which may account for some of the observed increase in PTC. This paper discusses the role of fragile site breakage in PTC development, external fragile site-inducing agents that may be potential risk factors for PTC, and how these factors are especially targeting women. Hindawi Publishing Corporation 2012 2012-06-11 /pmc/articles/PMC3384961/ /pubmed/22762011 http://dx.doi.org/10.1155/2012/927683 Text en Copyright © 2012 Laura W. Dillon et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Dillon, Laura W. Lehman, Christine E. Wang, Yuh-Hwa The Role of Fragile Sites in Sporadic Papillary Thyroid Carcinoma |
title | The Role of Fragile Sites in Sporadic Papillary Thyroid Carcinoma |
title_full | The Role of Fragile Sites in Sporadic Papillary Thyroid Carcinoma |
title_fullStr | The Role of Fragile Sites in Sporadic Papillary Thyroid Carcinoma |
title_full_unstemmed | The Role of Fragile Sites in Sporadic Papillary Thyroid Carcinoma |
title_short | The Role of Fragile Sites in Sporadic Papillary Thyroid Carcinoma |
title_sort | role of fragile sites in sporadic papillary thyroid carcinoma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384961/ https://www.ncbi.nlm.nih.gov/pubmed/22762011 http://dx.doi.org/10.1155/2012/927683 |
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