In Vivo Visualization of Heterogeneous Intratumoral Distribution of Hypoxia-Inducible Factor-1α Activity by the Fusion of High-Resolution SPECT and Morphological Imaging Tests

Purpose. We aimed to clearly visualize heterogeneous distribution of hypoxia-inducible factor 1α (HIF) activity in tumor tissues in vivo. Methods. We synthesized of (125)I-IPOS, a (125)I labeled chimeric protein probe, that would visualize HIF activity. The biodistribution of (125)I-IPOS in FM3A tum...

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Detalles Bibliográficos
Autores principales: Fujii, Hirofumi, Yamaguchi, Masayuki, Inoue, Kazumasa, Mutou, Yasuko, Ueda, Masashi, Saji, Hideo, Kizaka-Kondoh, Shinae, Moriyama, Noriyuki, Umeda, Izumi O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385015/
https://www.ncbi.nlm.nih.gov/pubmed/22778544
http://dx.doi.org/10.1155/2012/262741

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