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Changes in Serum Electrolytes, Urea, and Creatinine in Aloe Vera-treated Rats
This study was carried out to investigate the effect of Aloe vera extract (AvE) on serum electrolytes, urea, and creatinine as indices of renal function in Sprague-Dawley rats. Twelve male Sprague-Dawley rats weighing between 80 and 130 g were used. Rats were divided into two groups: The control and...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385221/ https://www.ncbi.nlm.nih.gov/pubmed/22754258 http://dx.doi.org/10.4103/0975-1483.96620 |
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author | Saka, WA Akhigbe, RE Popoola, OT Oyekunle, OS |
author_facet | Saka, WA Akhigbe, RE Popoola, OT Oyekunle, OS |
author_sort | Saka, WA |
collection | PubMed |
description | This study was carried out to investigate the effect of Aloe vera extract (AvE) on serum electrolytes, urea, and creatinine as indices of renal function in Sprague-Dawley rats. Twelve male Sprague-Dawley rats weighing between 80 and 130 g were used. Rats were divided into two groups: The control and the test groups (n=6). The test group received 1 ml of AvE daily for 28 days. Both the groups fed on standard rat chow and water ad libitum. The results showed a decrease in serum levels of sodium, and potassium, but an increase in the serum levels of bicarbonate, urea, and creatinine in the test group. The changes seen were, however, statistically insignificant, except for the serum levels of sodium and creatinine (P<0.05). It is thus concluded that AvE impairs renal handling of electrolytes with consequent hyponatremia and hypercreatinemia. However, this might be of therapeutic value in conditions associated with hypernatremia. |
format | Online Article Text |
id | pubmed-3385221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-33852212012-07-02 Changes in Serum Electrolytes, Urea, and Creatinine in Aloe Vera-treated Rats Saka, WA Akhigbe, RE Popoola, OT Oyekunle, OS J Young Pharm Pharmacology This study was carried out to investigate the effect of Aloe vera extract (AvE) on serum electrolytes, urea, and creatinine as indices of renal function in Sprague-Dawley rats. Twelve male Sprague-Dawley rats weighing between 80 and 130 g were used. Rats were divided into two groups: The control and the test groups (n=6). The test group received 1 ml of AvE daily for 28 days. Both the groups fed on standard rat chow and water ad libitum. The results showed a decrease in serum levels of sodium, and potassium, but an increase in the serum levels of bicarbonate, urea, and creatinine in the test group. The changes seen were, however, statistically insignificant, except for the serum levels of sodium and creatinine (P<0.05). It is thus concluded that AvE impairs renal handling of electrolytes with consequent hyponatremia and hypercreatinemia. However, this might be of therapeutic value in conditions associated with hypernatremia. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3385221/ /pubmed/22754258 http://dx.doi.org/10.4103/0975-1483.96620 Text en Copyright: © Journal of Young Pharmacists http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Pharmacology Saka, WA Akhigbe, RE Popoola, OT Oyekunle, OS Changes in Serum Electrolytes, Urea, and Creatinine in Aloe Vera-treated Rats |
title | Changes in Serum Electrolytes, Urea, and Creatinine in Aloe Vera-treated Rats |
title_full | Changes in Serum Electrolytes, Urea, and Creatinine in Aloe Vera-treated Rats |
title_fullStr | Changes in Serum Electrolytes, Urea, and Creatinine in Aloe Vera-treated Rats |
title_full_unstemmed | Changes in Serum Electrolytes, Urea, and Creatinine in Aloe Vera-treated Rats |
title_short | Changes in Serum Electrolytes, Urea, and Creatinine in Aloe Vera-treated Rats |
title_sort | changes in serum electrolytes, urea, and creatinine in aloe vera-treated rats |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385221/ https://www.ncbi.nlm.nih.gov/pubmed/22754258 http://dx.doi.org/10.4103/0975-1483.96620 |
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