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Glutamine: A novel approach to chemotherapy-induced toxicity

Treatment of cancer is associated with short- and long-term side-effects. Cancer produces a state of glutamine deficiency, which is further aggravated by toxic effects of chemotherapeutic agents leading to increased tolerance of tumor to chemotherapy as well as reduced tolerance of normal tissues to...

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Autores principales: Gaurav, Kumar, Goel, R. K., Shukla, Mridula, Pandey, Manoj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385273/
https://www.ncbi.nlm.nih.gov/pubmed/22754203
http://dx.doi.org/10.4103/0971-5851.96962
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author Gaurav, Kumar
Goel, R. K.
Shukla, Mridula
Pandey, Manoj
author_facet Gaurav, Kumar
Goel, R. K.
Shukla, Mridula
Pandey, Manoj
author_sort Gaurav, Kumar
collection PubMed
description Treatment of cancer is associated with short- and long-term side-effects. Cancer produces a state of glutamine deficiency, which is further aggravated by toxic effects of chemotherapeutic agents leading to increased tolerance of tumor to chemotherapy as well as reduced tolerance of normal tissues to the side-effects of chemotherapy. This article reviews the possible role of glutamine supplementation in reducing the serious adverse events in patients treated with anticancer drugs. The literature related to the possible role of glutamine in humans with cancer and the supportive evidence from animal studies was reviewed. Searches were made and the literature was retrieved using PUBMED, MEDLINE, COCHRANE LIBRARY, CENAHL and EMBASE, with a greater emphasis on the recent advances and clinical trials. Glutamine supplementation was found to protect against radiation-induced mucositis, anthracycline-induced cardiotoxicity and paclitaxel-related myalgias/arthralgias. Glutamine may prevent neurotoxicity of paclitaxel, cisplatin, oxaplatin bortezomib and lenolidamide, and is beneficial in the reduction of the dose-limiting gastrointestinal toxic effects of irinotecan and 5-FU-induced mucositis and stomatitis. Dietary glutamine reduces the severity of the immunosuppressive effect induced by methotrexate and improves the immune status of rats recovering from chemotherapy. In patients with acute myeloid leukemia requiring parenteral nutrition, glycyl-glutamine supplementation could hasten neutrophil recovery after intensive myelosuppressive chemotherapy. Current data supports the usefulness of glutamine supplementation in reducing complications of chemotherapy; however, paucity of clinical trials weakens the clear interpretation of these findings.
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spelling pubmed-33852732012-07-02 Glutamine: A novel approach to chemotherapy-induced toxicity Gaurav, Kumar Goel, R. K. Shukla, Mridula Pandey, Manoj Indian J Med Paediatr Oncol Review Article Treatment of cancer is associated with short- and long-term side-effects. Cancer produces a state of glutamine deficiency, which is further aggravated by toxic effects of chemotherapeutic agents leading to increased tolerance of tumor to chemotherapy as well as reduced tolerance of normal tissues to the side-effects of chemotherapy. This article reviews the possible role of glutamine supplementation in reducing the serious adverse events in patients treated with anticancer drugs. The literature related to the possible role of glutamine in humans with cancer and the supportive evidence from animal studies was reviewed. Searches were made and the literature was retrieved using PUBMED, MEDLINE, COCHRANE LIBRARY, CENAHL and EMBASE, with a greater emphasis on the recent advances and clinical trials. Glutamine supplementation was found to protect against radiation-induced mucositis, anthracycline-induced cardiotoxicity and paclitaxel-related myalgias/arthralgias. Glutamine may prevent neurotoxicity of paclitaxel, cisplatin, oxaplatin bortezomib and lenolidamide, and is beneficial in the reduction of the dose-limiting gastrointestinal toxic effects of irinotecan and 5-FU-induced mucositis and stomatitis. Dietary glutamine reduces the severity of the immunosuppressive effect induced by methotrexate and improves the immune status of rats recovering from chemotherapy. In patients with acute myeloid leukemia requiring parenteral nutrition, glycyl-glutamine supplementation could hasten neutrophil recovery after intensive myelosuppressive chemotherapy. Current data supports the usefulness of glutamine supplementation in reducing complications of chemotherapy; however, paucity of clinical trials weakens the clear interpretation of these findings. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3385273/ /pubmed/22754203 http://dx.doi.org/10.4103/0971-5851.96962 Text en Copyright: © Indian Journal of Medical and Paediatric Oncology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gaurav, Kumar
Goel, R. K.
Shukla, Mridula
Pandey, Manoj
Glutamine: A novel approach to chemotherapy-induced toxicity
title Glutamine: A novel approach to chemotherapy-induced toxicity
title_full Glutamine: A novel approach to chemotherapy-induced toxicity
title_fullStr Glutamine: A novel approach to chemotherapy-induced toxicity
title_full_unstemmed Glutamine: A novel approach to chemotherapy-induced toxicity
title_short Glutamine: A novel approach to chemotherapy-induced toxicity
title_sort glutamine: a novel approach to chemotherapy-induced toxicity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385273/
https://www.ncbi.nlm.nih.gov/pubmed/22754203
http://dx.doi.org/10.4103/0971-5851.96962
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AT pandeymanoj glutamineanovelapproachtochemotherapyinducedtoxicity