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A Cytoplasmic Dynein Tail Mutation Impairs Motor Processivity

Mutations in the tail of the cytoplasmic dynein molecule have been reported to cause neurodegenerative disease in mice. The mutant mouse strain Legs at Odd Angles (Loa) exhibits impaired retrograde axonal transport, but the molecular deficiencies in the mutant dynein molecule, and how they contribut...

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Detalles Bibliográficos
Autores principales:	Ori-McKenney, Kassandra M., Xu, Jing, Gross, Steven P., Vallee, Richard B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385513/ https://www.ncbi.nlm.nih.gov/pubmed/21102439 http://dx.doi.org/10.1038/ncb2127

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