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IL-18 Serum Level in Adult Onset Still's Disease: A Marker of Disease Activity

Introduction. Immunological factors seem to play a pivotal role in Adult Onset Still's Disease (AOSD). Among all, IL-18 cytokine is overexpressed and drives the inflammatory process. Objective. We aimed to investigate the levels of IL-18 in sera of Italian patients with AOSD and to assess its p...

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Autores principales: Colafrancesco, Serena, Priori, Roberta, Alessandri, Cristiano, Perricone, Carlo, Pendolino, Monica, Picarelli, Giovanna, Valesini, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385601/
https://www.ncbi.nlm.nih.gov/pubmed/22762008
http://dx.doi.org/10.1155/2012/156890
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author Colafrancesco, Serena
Priori, Roberta
Alessandri, Cristiano
Perricone, Carlo
Pendolino, Monica
Picarelli, Giovanna
Valesini, Guido
author_facet Colafrancesco, Serena
Priori, Roberta
Alessandri, Cristiano
Perricone, Carlo
Pendolino, Monica
Picarelli, Giovanna
Valesini, Guido
author_sort Colafrancesco, Serena
collection PubMed
description Introduction. Immunological factors seem to play a pivotal role in Adult Onset Still's Disease (AOSD). Among all, IL-18 cytokine is overexpressed and drives the inflammatory process. Objective. We aimed to investigate the levels of IL-18 in sera of Italian patients with AOSD and to assess its possible role as a marker of disease activity. Methods. IL-18 serum levels were determined by ELISA in 26 Italian patients with AOSD. Disease activity was assessed using Pouchot's criteria. As controls, 21 patients with Rheumatoid Arthritis (RA), 21 patients with Sjogren's Syndrome (SS), 20 patients with Systemic Lupus Erythematosus (SLE), and 21 healthy subjects (normal human sera, NHS) were evaluated. Results. IL-18 serum levels were significantly higher in patients with active AOSD than in non-active (P = 0.001) and control groups (RA P = 0.0070, SS P = 0.0029, SLE P = 0.0032, NHS P = 0.0004). A significant correlation between IL-18 serum levels and disease activity (P < 0.0001), and laboratory parameters as ferritin (P = 0.0127) and C-reactive protein (P = 0.0032) was demonstrated. Conclusions. Higher levels of IL-18 are detected in active AODS patients and correlate with disease activity and inflammatory laboratory features. ROC-AUC analysis of the serum concentration of IL-18 suggests that it can be considered a diagnostic marker of AOSD. This paper supports the targeting of this cytokine as a possible therapeutic option in AOSD.
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spelling pubmed-33856012012-07-03 IL-18 Serum Level in Adult Onset Still's Disease: A Marker of Disease Activity Colafrancesco, Serena Priori, Roberta Alessandri, Cristiano Perricone, Carlo Pendolino, Monica Picarelli, Giovanna Valesini, Guido Int J Inflam Clinical Study Introduction. Immunological factors seem to play a pivotal role in Adult Onset Still's Disease (AOSD). Among all, IL-18 cytokine is overexpressed and drives the inflammatory process. Objective. We aimed to investigate the levels of IL-18 in sera of Italian patients with AOSD and to assess its possible role as a marker of disease activity. Methods. IL-18 serum levels were determined by ELISA in 26 Italian patients with AOSD. Disease activity was assessed using Pouchot's criteria. As controls, 21 patients with Rheumatoid Arthritis (RA), 21 patients with Sjogren's Syndrome (SS), 20 patients with Systemic Lupus Erythematosus (SLE), and 21 healthy subjects (normal human sera, NHS) were evaluated. Results. IL-18 serum levels were significantly higher in patients with active AOSD than in non-active (P = 0.001) and control groups (RA P = 0.0070, SS P = 0.0029, SLE P = 0.0032, NHS P = 0.0004). A significant correlation between IL-18 serum levels and disease activity (P < 0.0001), and laboratory parameters as ferritin (P = 0.0127) and C-reactive protein (P = 0.0032) was demonstrated. Conclusions. Higher levels of IL-18 are detected in active AODS patients and correlate with disease activity and inflammatory laboratory features. ROC-AUC analysis of the serum concentration of IL-18 suggests that it can be considered a diagnostic marker of AOSD. This paper supports the targeting of this cytokine as a possible therapeutic option in AOSD. Hindawi Publishing Corporation 2012 2012-06-18 /pmc/articles/PMC3385601/ /pubmed/22762008 http://dx.doi.org/10.1155/2012/156890 Text en Copyright © 2012 Serena Colafrancesco et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Colafrancesco, Serena
Priori, Roberta
Alessandri, Cristiano
Perricone, Carlo
Pendolino, Monica
Picarelli, Giovanna
Valesini, Guido
IL-18 Serum Level in Adult Onset Still's Disease: A Marker of Disease Activity
title IL-18 Serum Level in Adult Onset Still's Disease: A Marker of Disease Activity
title_full IL-18 Serum Level in Adult Onset Still's Disease: A Marker of Disease Activity
title_fullStr IL-18 Serum Level in Adult Onset Still's Disease: A Marker of Disease Activity
title_full_unstemmed IL-18 Serum Level in Adult Onset Still's Disease: A Marker of Disease Activity
title_short IL-18 Serum Level in Adult Onset Still's Disease: A Marker of Disease Activity
title_sort il-18 serum level in adult onset still's disease: a marker of disease activity
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385601/
https://www.ncbi.nlm.nih.gov/pubmed/22762008
http://dx.doi.org/10.1155/2012/156890
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