Role of Prostaglandins in Neuroinflammatory and Neurodegenerative Diseases

Increasing data demonstrates that inflammation participates in the pathophysiology of neurodegenerative diseases. Among the different inflammatory mediators involved, prostaglandins play an important role. The effects induced by prostaglandins might be mediated by activation of their known receptors...

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Detalles Bibliográficos
Autores principales: Lima, Isabel Vieira de Assis, Bastos, Leandro Francisco Silva, Limborço-Filho, Marcelo, Fiebich, Bernd L., de Oliveira, Antonio Carlos Pinheiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385693/
https://www.ncbi.nlm.nih.gov/pubmed/22778499
http://dx.doi.org/10.1155/2012/946813
Descripción
Sumario:Increasing data demonstrates that inflammation participates in the pathophysiology of neurodegenerative diseases. Among the different inflammatory mediators involved, prostaglandins play an important role. The effects induced by prostaglandins might be mediated by activation of their known receptors or by nonclassical mechanisms. In the present paper, we discuss the evidences that link prostaglandins, as well as the enzymes that produce them, to some neurological diseases.

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