Cargando…
Haemocompatibility and ion exchange capability of nanocellulose polypyrrole membranes intended for blood purification
Composites of nanocellulose and the conductive polymer polypyrrole (PPy) are presented as candidates for a new generation of haemodialysis membranes. The composites may combine active ion exchange with passive ultrafiltration, and the large surface area (about 80 m(2) g(−1)) could potentially provid...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385765/ https://www.ncbi.nlm.nih.gov/pubmed/22298813 http://dx.doi.org/10.1098/rsif.2012.0019 |
_version_ | 1782236918810935296 |
---|---|
author | Ferraz, Natalia Carlsson, Daniel O. Hong, Jaan Larsson, Rolf Fellström, Bengt Nyholm, Leif Strømme, Maria Mihranyan, Albert |
author_facet | Ferraz, Natalia Carlsson, Daniel O. Hong, Jaan Larsson, Rolf Fellström, Bengt Nyholm, Leif Strømme, Maria Mihranyan, Albert |
author_sort | Ferraz, Natalia |
collection | PubMed |
description | Composites of nanocellulose and the conductive polymer polypyrrole (PPy) are presented as candidates for a new generation of haemodialysis membranes. The composites may combine active ion exchange with passive ultrafiltration, and the large surface area (about 80 m(2) g(−1)) could potentially provide compact dialysers. Herein, the haemocompatibility of the novel membranes and the feasibility of effectively removing small uraemic toxins by potential-controlled ion exchange were studied. The thrombogenic properties of the composites were improved by applying a stable heparin coating. In terms of platelet adhesion and thrombin generation, the composites were comparable with haemocompatible polymer polysulphone, and regarding complement activation, the composites were more biocompatible than commercially available membranes. It was possible to extract phosphate and oxalate ions from solutions with physiological pH and the same tonicity as that of the blood. The exchange capacity of the materials was found to be 600 ± 26 and 706 ± 31 μmol g(−1) in a 0.1 M solution (pH 7.4) and in an isotonic solution of phosphate, respectively. The corresponding values with oxalate were 523 ± 5 in a 0.1 M solution (pH 7.4) and 610 ± 1 μmol g(−1) in an isotonic solution. The heparinized PPy–cellulose composite is consequently a promising haemodialysis material, with respect to both potential-controlled extraction of small uraemic toxins and haemocompatibility. |
format | Online Article Text |
id | pubmed-3385765 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-33857652012-06-29 Haemocompatibility and ion exchange capability of nanocellulose polypyrrole membranes intended for blood purification Ferraz, Natalia Carlsson, Daniel O. Hong, Jaan Larsson, Rolf Fellström, Bengt Nyholm, Leif Strømme, Maria Mihranyan, Albert J R Soc Interface Research Articles Composites of nanocellulose and the conductive polymer polypyrrole (PPy) are presented as candidates for a new generation of haemodialysis membranes. The composites may combine active ion exchange with passive ultrafiltration, and the large surface area (about 80 m(2) g(−1)) could potentially provide compact dialysers. Herein, the haemocompatibility of the novel membranes and the feasibility of effectively removing small uraemic toxins by potential-controlled ion exchange were studied. The thrombogenic properties of the composites were improved by applying a stable heparin coating. In terms of platelet adhesion and thrombin generation, the composites were comparable with haemocompatible polymer polysulphone, and regarding complement activation, the composites were more biocompatible than commercially available membranes. It was possible to extract phosphate and oxalate ions from solutions with physiological pH and the same tonicity as that of the blood. The exchange capacity of the materials was found to be 600 ± 26 and 706 ± 31 μmol g(−1) in a 0.1 M solution (pH 7.4) and in an isotonic solution of phosphate, respectively. The corresponding values with oxalate were 523 ± 5 in a 0.1 M solution (pH 7.4) and 610 ± 1 μmol g(−1) in an isotonic solution. The heparinized PPy–cellulose composite is consequently a promising haemodialysis material, with respect to both potential-controlled extraction of small uraemic toxins and haemocompatibility. The Royal Society 2012-08-07 2012-02-01 /pmc/articles/PMC3385765/ /pubmed/22298813 http://dx.doi.org/10.1098/rsif.2012.0019 Text en This journal is © 2012 The Royal Society http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Ferraz, Natalia Carlsson, Daniel O. Hong, Jaan Larsson, Rolf Fellström, Bengt Nyholm, Leif Strømme, Maria Mihranyan, Albert Haemocompatibility and ion exchange capability of nanocellulose polypyrrole membranes intended for blood purification |
title | Haemocompatibility and ion exchange capability of nanocellulose polypyrrole membranes intended for blood purification |
title_full | Haemocompatibility and ion exchange capability of nanocellulose polypyrrole membranes intended for blood purification |
title_fullStr | Haemocompatibility and ion exchange capability of nanocellulose polypyrrole membranes intended for blood purification |
title_full_unstemmed | Haemocompatibility and ion exchange capability of nanocellulose polypyrrole membranes intended for blood purification |
title_short | Haemocompatibility and ion exchange capability of nanocellulose polypyrrole membranes intended for blood purification |
title_sort | haemocompatibility and ion exchange capability of nanocellulose polypyrrole membranes intended for blood purification |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385765/ https://www.ncbi.nlm.nih.gov/pubmed/22298813 http://dx.doi.org/10.1098/rsif.2012.0019 |
work_keys_str_mv | AT ferraznatalia haemocompatibilityandionexchangecapabilityofnanocellulosepolypyrrolemembranesintendedforbloodpurification AT carlssondanielo haemocompatibilityandionexchangecapabilityofnanocellulosepolypyrrolemembranesintendedforbloodpurification AT hongjaan haemocompatibilityandionexchangecapabilityofnanocellulosepolypyrrolemembranesintendedforbloodpurification AT larssonrolf haemocompatibilityandionexchangecapabilityofnanocellulosepolypyrrolemembranesintendedforbloodpurification AT fellstrombengt haemocompatibilityandionexchangecapabilityofnanocellulosepolypyrrolemembranesintendedforbloodpurification AT nyholmleif haemocompatibilityandionexchangecapabilityofnanocellulosepolypyrrolemembranesintendedforbloodpurification AT strømmemaria haemocompatibilityandionexchangecapabilityofnanocellulosepolypyrrolemembranesintendedforbloodpurification AT mihranyanalbert haemocompatibilityandionexchangecapabilityofnanocellulosepolypyrrolemembranesintendedforbloodpurification |