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The future of ciliary and flagellar membrane research
There has been a dramatic shift of attention from the ciliary axoneme to the ciliary membrane, much of this driven by the appreciation that cilia play a widespread role in sensory reception and cellular signaling. This Perspective focuses attention on some of the poorly understood aspects of ciliary...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The American Society for Cell Biology
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386205/ https://www.ncbi.nlm.nih.gov/pubmed/22745341 http://dx.doi.org/10.1091/mbc.E12-01-0073 |
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author | Bloodgood, Robert A. |
author_facet | Bloodgood, Robert A. |
author_sort | Bloodgood, Robert A. |
collection | PubMed |
description | There has been a dramatic shift of attention from the ciliary axoneme to the ciliary membrane, much of this driven by the appreciation that cilia play a widespread role in sensory reception and cellular signaling. This Perspective focuses attention on some of the poorly understood aspects of ciliary membranes, including the establishment of ciliary and periciliary membrane domains, the trafficking of membrane components into and out of these membrane domains, the nonuniform distribution of ciliary membrane components, the regulation of membrane morphogenesis, functional collaboration between the axoneme and the membrane, and the evolving field of therapeutics targeted at the ciliary membrane. |
format | Online Article Text |
id | pubmed-3386205 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The American Society for Cell Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-33862052012-09-16 The future of ciliary and flagellar membrane research Bloodgood, Robert A. Mol Biol Cell Perspectives There has been a dramatic shift of attention from the ciliary axoneme to the ciliary membrane, much of this driven by the appreciation that cilia play a widespread role in sensory reception and cellular signaling. This Perspective focuses attention on some of the poorly understood aspects of ciliary membranes, including the establishment of ciliary and periciliary membrane domains, the trafficking of membrane components into and out of these membrane domains, the nonuniform distribution of ciliary membrane components, the regulation of membrane morphogenesis, functional collaboration between the axoneme and the membrane, and the evolving field of therapeutics targeted at the ciliary membrane. The American Society for Cell Biology 2012-07-01 /pmc/articles/PMC3386205/ /pubmed/22745341 http://dx.doi.org/10.1091/mbc.E12-01-0073 Text en © 2012 Bloodgood. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell BD; are registered trademarks of The American Society of Cell Biology. |
spellingShingle | Perspectives Bloodgood, Robert A. The future of ciliary and flagellar membrane research |
title | The future of ciliary and flagellar membrane research |
title_full | The future of ciliary and flagellar membrane research |
title_fullStr | The future of ciliary and flagellar membrane research |
title_full_unstemmed | The future of ciliary and flagellar membrane research |
title_short | The future of ciliary and flagellar membrane research |
title_sort | future of ciliary and flagellar membrane research |
topic | Perspectives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386205/ https://www.ncbi.nlm.nih.gov/pubmed/22745341 http://dx.doi.org/10.1091/mbc.E12-01-0073 |
work_keys_str_mv | AT bloodgoodroberta thefutureofciliaryandflagellarmembraneresearch AT bloodgoodroberta futureofciliaryandflagellarmembraneresearch |