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GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kγ activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production

Most chemoattractants for neutrophils bind to the Gα(i) family of heterotrimeric G protein–coupled receptors (GPCRs) and release Gβγ subunits to activate chemotaxis and superoxide production. GIT2, a GTPase-activating protein for Arf1, forms a complex with Gβγ and is integral for directional sensing...

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Detalles Bibliográficos
Autores principales:	Mazaki, Yuichi, Nishimura, Yasuharu, Sabe, Hisataka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386210/ https://www.ncbi.nlm.nih.gov/pubmed/22573891 http://dx.doi.org/10.1091/mbc.E12-01-0062

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