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The Rad4(TopBP1) ATR-Activation Domain Functions in G1/S Phase in a Chromatin-Dependent Manner

DNA damage checkpoint activation can be subdivided in two steps: initial activation and signal amplification. The events distinguishing these two phases and their genetic determinants remain obscure. TopBP1, a mediator protein containing multiple BRCT domains, binds to and activates the ATR/ATRIP co...

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Detalles Bibliográficos
Autores principales:	Lin, Su-Jiun, Wardlaw, Christopher P., Morishita, Takashi, Miyabe, Izumi, Chahwan, Charly, Caspari, Thomas, Schmidt, Ulrike, Carr, Antony M., Garcia, Valerie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386226/ https://www.ncbi.nlm.nih.gov/pubmed/22761595 http://dx.doi.org/10.1371/journal.pgen.1002801

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