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Cerebrospinal Fluid Space Alterations in Melancholic Depression

Melancholic depression is a biologically homogeneous clinical entity in which structural brain alterations have been described. Interestingly, reports of structural alterations in melancholia include volume increases in Cerebro-Spinal Fluid (CSF) spaces. However, there are no previous reports of CSF...

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Autores principales: Via, Esther, Cardoner, Narcís, Pujol, Jesús, Martínez-Zalacaín, Ignacio, Hernández-Ribas, Rosa, Urretavizacaya, Mikel, López-Solà, Marina, Deus, Joan, Menchón, José Manuel, Soriano-Mas, Carles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386250/
https://www.ncbi.nlm.nih.gov/pubmed/22761673
http://dx.doi.org/10.1371/journal.pone.0038299
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author Via, Esther
Cardoner, Narcís
Pujol, Jesús
Martínez-Zalacaín, Ignacio
Hernández-Ribas, Rosa
Urretavizacaya, Mikel
López-Solà, Marina
Deus, Joan
Menchón, José Manuel
Soriano-Mas, Carles
author_facet Via, Esther
Cardoner, Narcís
Pujol, Jesús
Martínez-Zalacaín, Ignacio
Hernández-Ribas, Rosa
Urretavizacaya, Mikel
López-Solà, Marina
Deus, Joan
Menchón, José Manuel
Soriano-Mas, Carles
author_sort Via, Esther
collection PubMed
description Melancholic depression is a biologically homogeneous clinical entity in which structural brain alterations have been described. Interestingly, reports of structural alterations in melancholia include volume increases in Cerebro-Spinal Fluid (CSF) spaces. However, there are no previous reports of CSF volume alterations using automated whole-brain voxel-wise approaches, as tissue classification algorithms have been traditionally regarded as less reliable for CSF segmentation. Here we aimed to assess CSF volumetric alterations in melancholic depression and their clinical correlates by means of a novel segmentation algorithm (‘new segment’, as implemented in the software Statistical Parametric Mapping-SPM8), incorporating specific features that may improve CSF segmentation. A three-dimensional Magnetic Resonance Image (MRI) was obtained from seventy patients with melancholic depression and forty healthy control subjects. Although imaging data were pre-processed with the ‘new segment’ algorithm, in order to obtain a comparison with previous segmentation approaches, tissue segmentation was also performed with the ‘unified segmentation’ approach. Melancholic patients showed a CSF volume increase in the region of the left Sylvian fissure, and a CSF volume decrease in the subarachnoid spaces surrounding medial and lateral parietal cortices. Furthermore, CSF increases in the left Sylvian fissure were negatively correlated with the reduction percentage of depressive symptoms at discharge. None of these results were replicated with the ‘unified segmentation’ approach. By contrast, between-group differences in the left Sylvian fissure were replicated with a non-automated quantification of the CSF content of this region. Left Sylvian fissure alterations reported here are in agreement with previous findings from non-automated CSF assessments, and also with other reports of gray and white matter insular alterations in depressive samples using automated approaches. The reliable characterization of CSF alterations may help in the comprehensive characterization of brain structural abnormalities in psychiatric samples and in the development of etiopathogenic hypotheses relating to the disorders.
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spelling pubmed-33862502012-07-03 Cerebrospinal Fluid Space Alterations in Melancholic Depression Via, Esther Cardoner, Narcís Pujol, Jesús Martínez-Zalacaín, Ignacio Hernández-Ribas, Rosa Urretavizacaya, Mikel López-Solà, Marina Deus, Joan Menchón, José Manuel Soriano-Mas, Carles PLoS One Research Article Melancholic depression is a biologically homogeneous clinical entity in which structural brain alterations have been described. Interestingly, reports of structural alterations in melancholia include volume increases in Cerebro-Spinal Fluid (CSF) spaces. However, there are no previous reports of CSF volume alterations using automated whole-brain voxel-wise approaches, as tissue classification algorithms have been traditionally regarded as less reliable for CSF segmentation. Here we aimed to assess CSF volumetric alterations in melancholic depression and their clinical correlates by means of a novel segmentation algorithm (‘new segment’, as implemented in the software Statistical Parametric Mapping-SPM8), incorporating specific features that may improve CSF segmentation. A three-dimensional Magnetic Resonance Image (MRI) was obtained from seventy patients with melancholic depression and forty healthy control subjects. Although imaging data were pre-processed with the ‘new segment’ algorithm, in order to obtain a comparison with previous segmentation approaches, tissue segmentation was also performed with the ‘unified segmentation’ approach. Melancholic patients showed a CSF volume increase in the region of the left Sylvian fissure, and a CSF volume decrease in the subarachnoid spaces surrounding medial and lateral parietal cortices. Furthermore, CSF increases in the left Sylvian fissure were negatively correlated with the reduction percentage of depressive symptoms at discharge. None of these results were replicated with the ‘unified segmentation’ approach. By contrast, between-group differences in the left Sylvian fissure were replicated with a non-automated quantification of the CSF content of this region. Left Sylvian fissure alterations reported here are in agreement with previous findings from non-automated CSF assessments, and also with other reports of gray and white matter insular alterations in depressive samples using automated approaches. The reliable characterization of CSF alterations may help in the comprehensive characterization of brain structural abnormalities in psychiatric samples and in the development of etiopathogenic hypotheses relating to the disorders. Public Library of Science 2012-06-28 /pmc/articles/PMC3386250/ /pubmed/22761673 http://dx.doi.org/10.1371/journal.pone.0038299 Text en Via et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Via, Esther
Cardoner, Narcís
Pujol, Jesús
Martínez-Zalacaín, Ignacio
Hernández-Ribas, Rosa
Urretavizacaya, Mikel
López-Solà, Marina
Deus, Joan
Menchón, José Manuel
Soriano-Mas, Carles
Cerebrospinal Fluid Space Alterations in Melancholic Depression
title Cerebrospinal Fluid Space Alterations in Melancholic Depression
title_full Cerebrospinal Fluid Space Alterations in Melancholic Depression
title_fullStr Cerebrospinal Fluid Space Alterations in Melancholic Depression
title_full_unstemmed Cerebrospinal Fluid Space Alterations in Melancholic Depression
title_short Cerebrospinal Fluid Space Alterations in Melancholic Depression
title_sort cerebrospinal fluid space alterations in melancholic depression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386250/
https://www.ncbi.nlm.nih.gov/pubmed/22761673
http://dx.doi.org/10.1371/journal.pone.0038299
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