GABA(B) Receptor Subunit GB1 at the Cell Surface Independently Activates ERK1/2 through IGF-1R Transactivation

BACKGROUND: Functional GABA(B) receptor is believed to require hetero-dimerization between GABA(B1) (GB1) and GABA(B2) (GB2) subunits. The GB1 extracellular domain is required for ligand binding, and the GB2 trans-membrane domain is responsible for coupling to G proteins. Atypical GABA(B) receptor r...

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Detalles Bibliográficos
Autores principales: Baloucoune, Guillaume A., Chun, Lei, Zhang, Wenhua, Xu, Chanjuan, Huang, Siluo, Sun, Qian, Wang, Yunyun, Tu, Haijun, Liu, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386256/
https://www.ncbi.nlm.nih.gov/pubmed/22761875
http://dx.doi.org/10.1371/journal.pone.0039698

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