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Structure-Function Analysis of Human TYW2 Enzyme Required for the Biosynthesis of a Highly Modified Wybutosine (yW) Base in Phenylalanine-tRNA

Posttranscriptional modifications are critical for structure and function of tRNAs. Wybutosine (yW) and its derivatives are hyper-modified guanosines found at the position 37 of eukaryotic and archaeal tRNA(Phe). TYW2 is an enzyme that catalyzes α-amino-α-carboxypropyl transfer activity at the third...

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Detalles Bibliográficos
Autores principales:	Rodriguez, Virginia, Vasudevan, Sona, Noma, Akiko, Carlson, Bradley A., Green, Jeffrey E., Suzuki, Tsutomu, Chandrasekharappa, Settara C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386263/ https://www.ncbi.nlm.nih.gov/pubmed/22761755 http://dx.doi.org/10.1371/journal.pone.0039297

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