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An efficient multi-locus mixed model approach for genome-wide association studies in structured populations
Population structure causes genome-wide linkage disequilibrium between unlinked loci, leading to statistical confounding in genome-wide association studies. Mixed models have been shown to handle the confounding effects of a diffuse background of large numbers of loci of small effect well, but do no...
Autores principales: | Segura, Vincent, Vilhjálmsson, Bjarni J., Platt, Alexander, Korte, Arthur, Seren, Ümit, Long, Quan, Nordborg, Magnus |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386481/ https://www.ncbi.nlm.nih.gov/pubmed/22706313 http://dx.doi.org/10.1038/ng.2314 |
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