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Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis : Getting to Know the Unknown
Systemic lupus erythematosus is characterized by a breakdown of self-tolerance and production of autoantibodies. Kidney involvement (i.e., lupus nephritis) is both common and severe and can result in permanent damage within the glomerular, vascular, and tubulo-interstitial compartments of the kidney...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386553/ https://www.ncbi.nlm.nih.gov/pubmed/22761629 http://dx.doi.org/10.1155/2012/139365 |
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author | Yung, Susan Chan, Tak Mao |
author_facet | Yung, Susan Chan, Tak Mao |
author_sort | Yung, Susan |
collection | PubMed |
description | Systemic lupus erythematosus is characterized by a breakdown of self-tolerance and production of autoantibodies. Kidney involvement (i.e., lupus nephritis) is both common and severe and can result in permanent damage within the glomerular, vascular, and tubulo-interstitial compartments of the kidney, leading to acute or chronic renal failure. Accumulating evidence shows that anti-dsDNA antibodies play a critical role in the pathogenesis of lupus nephritis through their binding to cell surface proteins of resident kidney cells, thereby triggering the downstream activation of signaling pathways and the release of mediators of inflammation and fibrosis. This paper describes the mechanisms through which autoantibodies interact with resident renal cells and how this interaction plays a part in disease pathogenesis that ultimately leads to structural and functional alterations in lupus nephritis. |
format | Online Article Text |
id | pubmed-3386553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33865532012-07-03 Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis : Getting to Know the Unknown Yung, Susan Chan, Tak Mao Clin Dev Immunol Review Article Systemic lupus erythematosus is characterized by a breakdown of self-tolerance and production of autoantibodies. Kidney involvement (i.e., lupus nephritis) is both common and severe and can result in permanent damage within the glomerular, vascular, and tubulo-interstitial compartments of the kidney, leading to acute or chronic renal failure. Accumulating evidence shows that anti-dsDNA antibodies play a critical role in the pathogenesis of lupus nephritis through their binding to cell surface proteins of resident kidney cells, thereby triggering the downstream activation of signaling pathways and the release of mediators of inflammation and fibrosis. This paper describes the mechanisms through which autoantibodies interact with resident renal cells and how this interaction plays a part in disease pathogenesis that ultimately leads to structural and functional alterations in lupus nephritis. Hindawi Publishing Corporation 2012 2012-06-14 /pmc/articles/PMC3386553/ /pubmed/22761629 http://dx.doi.org/10.1155/2012/139365 Text en Copyright © 2012 S. Yung and T. M. Chan. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Yung, Susan Chan, Tak Mao Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis : Getting to Know the Unknown |
title | Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis : Getting to Know the Unknown |
title_full | Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis : Getting to Know the Unknown |
title_fullStr | Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis : Getting to Know the Unknown |
title_full_unstemmed | Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis : Getting to Know the Unknown |
title_short | Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis : Getting to Know the Unknown |
title_sort | autoantibodies and resident renal cells in the pathogenesis of lupus nephritis : getting to know the unknown |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386553/ https://www.ncbi.nlm.nih.gov/pubmed/22761629 http://dx.doi.org/10.1155/2012/139365 |
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