Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions

Dermatitis herpetiformis (DH) is a rare autoimmune disease linked to gluten sensitivity with a chronic-relapsing course. It is currently considered to be the specific cutaneous manifestation of celiac disease (CD). Both conditions are mediated by the IgA class of autoantibodies, and the diagnosis of...

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Detalles Bibliográficos
Autores principales: Bonciani, Diletta, Verdelli, Alice, Bonciolini, Veronica, D'Errico, Antonietta, Antiga, Emiliano, Fabbri, Paolo, Caproni, Marzia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386601/
https://www.ncbi.nlm.nih.gov/pubmed/22778763
http://dx.doi.org/10.1155/2012/239691
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author Bonciani, Diletta
Verdelli, Alice
Bonciolini, Veronica
D'Errico, Antonietta
Antiga, Emiliano
Fabbri, Paolo
Caproni, Marzia
author_facet Bonciani, Diletta
Verdelli, Alice
Bonciolini, Veronica
D'Errico, Antonietta
Antiga, Emiliano
Fabbri, Paolo
Caproni, Marzia
author_sort Bonciani, Diletta
collection PubMed
description Dermatitis herpetiformis (DH) is a rare autoimmune disease linked to gluten sensitivity with a chronic-relapsing course. It is currently considered to be the specific cutaneous manifestation of celiac disease (CD). Both conditions are mediated by the IgA class of autoantibodies, and the diagnosis of DH is dependent on the detection of granular deposits of IgA in the skin. There is an underlying genetic predisposition to the development of DH, but environmental factors are also important. This paper describes these different factors and discusses the known mechanism that lead to the development of skin lesions.
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spelling pubmed-33866012012-07-09 Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions Bonciani, Diletta Verdelli, Alice Bonciolini, Veronica D'Errico, Antonietta Antiga, Emiliano Fabbri, Paolo Caproni, Marzia Clin Dev Immunol Review Article Dermatitis herpetiformis (DH) is a rare autoimmune disease linked to gluten sensitivity with a chronic-relapsing course. It is currently considered to be the specific cutaneous manifestation of celiac disease (CD). Both conditions are mediated by the IgA class of autoantibodies, and the diagnosis of DH is dependent on the detection of granular deposits of IgA in the skin. There is an underlying genetic predisposition to the development of DH, but environmental factors are also important. This paper describes these different factors and discusses the known mechanism that lead to the development of skin lesions. Hindawi Publishing Corporation 2012 2012-06-07 /pmc/articles/PMC3386601/ /pubmed/22778763 http://dx.doi.org/10.1155/2012/239691 Text en Copyright © 2012 Diletta Bonciani et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bonciani, Diletta
Verdelli, Alice
Bonciolini, Veronica
D'Errico, Antonietta
Antiga, Emiliano
Fabbri, Paolo
Caproni, Marzia
Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions
title Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions
title_full Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions
title_fullStr Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions
title_full_unstemmed Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions
title_short Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions
title_sort dermatitis herpetiformis: from the genetics to the development of skin lesions
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386601/
https://www.ncbi.nlm.nih.gov/pubmed/22778763
http://dx.doi.org/10.1155/2012/239691
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