Classifying the Topology of AHL-Driven Quorum Sensing Circuits in Proteobacterial Genomes

Virulence and adaptability of many Gram-negative bacterial species are associated with an N-acylhomoserine lactone (AHL) gene regulation mechanism called quorum sensing (QS). The arrangement of quorum sensing genes is variable throughout bacterial genomes, although there are unifying themes that are...

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Detalles Bibliográficos
Autores principales: Gelencsér, Zsolt, Choudhary, Kumari Sonal, Coutinho, Bruna Goncalves, Hudaiberdiev, Sanjarbek, Galbáts, Borisz, Venturi, Vittorio, Pongor, Sándor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386692/
https://www.ncbi.nlm.nih.gov/pubmed/22778593
http://dx.doi.org/10.3390/s120505432
Descripción
Sumario:Virulence and adaptability of many Gram-negative bacterial species are associated with an N-acylhomoserine lactone (AHL) gene regulation mechanism called quorum sensing (QS). The arrangement of quorum sensing genes is variable throughout bacterial genomes, although there are unifying themes that are common among the various topological arrangements. A bioinformatics survey of 1,403 complete bacterial genomes revealed characteristic gene topologies in 152 genomes that could be classified into 16 topological groups. We developed a concise notation for the patterns and show that the sequences of LuxR regulators and LuxI autoinducer synthase proteins cluster according to the topological patterns. The annotated topologies are deposited online with links to sequences and genome annotations at http://bacteria.itk.ppke.hu/QStopologies/.

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