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Serum Visfatin Levels, Adiposity and Glucose Metabolism in Obese Adolescents
Objective: Visfatin, an adipokine, has insulin-mimetic effects. The main determinants of both the production and the physiologic role of visfatin are still unclear. The aim of this study is to determine the relation of serum visfatin to adiposity and glucose metabolism. Methods: 40 pubertal adolesce...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386777/ https://www.ncbi.nlm.nih.gov/pubmed/22672864 http://dx.doi.org/10.4274/Jcrpe.547 |
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author | Taşkesen, Derya Kirel, Birgül Us, Tercan |
author_facet | Taşkesen, Derya Kirel, Birgül Us, Tercan |
author_sort | Taşkesen, Derya |
collection | PubMed |
description | Objective: Visfatin, an adipokine, has insulin-mimetic effects. The main determinants of both the production and the physiologic role of visfatin are still unclear. The aim of this study is to determine the relation of serum visfatin to adiposity and glucose metabolism. Methods: 40 pubertal adolescents (20 females, 20 males; age range: 9-17 years) with exogenous obesity and 20 age- and sex-matched healthy adolescents (10 females, 10 males) were enrolled in the study. Oral glucose tolerance test (OGTT) was performed in the obese group. Serum glucose, insulin and visfatin levels were analyzed in the fasting state in the controls and at 0, 60 and 120 minutes during the OGTT in the obese group. Results: The obese group had higher serum visfatin levels than the control group [11.6 (3.3-26) ng/mL vs. 7.5 (3.3-10.5) ng/mL, p<0.001]. Visfatin levels were correlated positively with body mass index, waist/hip ratio, insulin, and homeostasis model assessment for insulin resistance and negatively with glucose/insulin ratio in the combined group (obese subjects plus controls). Visfatin levels were essentially similar in obese subjects with and without insulin resistance (p>0.05). Serum visfatin levels did not change at 60 and 120 minutes of the OGTT compared to the baseline levels (p>0.05). Conclusions: Serum visfatin levels are elevated in obese adolescents and do not change with acute changes in glucose metabolism. Visfatin levels are related with adiposity and glucose metabolism parameters. However, the role and contribution of adiposity and glucose metabolism to the circulating visfatin levels in obese patients remain to be explored. Conflict of interest:None declared. |
format | Online Article Text |
id | pubmed-3386777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-33867772012-07-09 Serum Visfatin Levels, Adiposity and Glucose Metabolism in Obese Adolescents Taşkesen, Derya Kirel, Birgül Us, Tercan J Clin Res Pediatr Endocrinol Original Article Objective: Visfatin, an adipokine, has insulin-mimetic effects. The main determinants of both the production and the physiologic role of visfatin are still unclear. The aim of this study is to determine the relation of serum visfatin to adiposity and glucose metabolism. Methods: 40 pubertal adolescents (20 females, 20 males; age range: 9-17 years) with exogenous obesity and 20 age- and sex-matched healthy adolescents (10 females, 10 males) were enrolled in the study. Oral glucose tolerance test (OGTT) was performed in the obese group. Serum glucose, insulin and visfatin levels were analyzed in the fasting state in the controls and at 0, 60 and 120 minutes during the OGTT in the obese group. Results: The obese group had higher serum visfatin levels than the control group [11.6 (3.3-26) ng/mL vs. 7.5 (3.3-10.5) ng/mL, p<0.001]. Visfatin levels were correlated positively with body mass index, waist/hip ratio, insulin, and homeostasis model assessment for insulin resistance and negatively with glucose/insulin ratio in the combined group (obese subjects plus controls). Visfatin levels were essentially similar in obese subjects with and without insulin resistance (p>0.05). Serum visfatin levels did not change at 60 and 120 minutes of the OGTT compared to the baseline levels (p>0.05). Conclusions: Serum visfatin levels are elevated in obese adolescents and do not change with acute changes in glucose metabolism. Visfatin levels are related with adiposity and glucose metabolism parameters. However, the role and contribution of adiposity and glucose metabolism to the circulating visfatin levels in obese patients remain to be explored. Conflict of interest:None declared. Galenos Publishing 2012-06 2012-06-09 /pmc/articles/PMC3386777/ /pubmed/22672864 http://dx.doi.org/10.4274/Jcrpe.547 Text en © Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Taşkesen, Derya Kirel, Birgül Us, Tercan Serum Visfatin Levels, Adiposity and Glucose Metabolism in Obese Adolescents |
title | Serum Visfatin Levels, Adiposity and Glucose Metabolism in Obese Adolescents |
title_full | Serum Visfatin Levels, Adiposity and Glucose Metabolism in Obese Adolescents |
title_fullStr | Serum Visfatin Levels, Adiposity and Glucose Metabolism in Obese Adolescents |
title_full_unstemmed | Serum Visfatin Levels, Adiposity and Glucose Metabolism in Obese Adolescents |
title_short | Serum Visfatin Levels, Adiposity and Glucose Metabolism in Obese Adolescents |
title_sort | serum visfatin levels, adiposity and glucose metabolism in obese adolescents |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386777/ https://www.ncbi.nlm.nih.gov/pubmed/22672864 http://dx.doi.org/10.4274/Jcrpe.547 |
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