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Altering APP Proteolysis: Increasing sAPPalpha Production by Targeting Dimerization of the APP Ectodomain

One of the events associated with Alzheimer's disease is the dysregulation of α- versus β-cleavage of the amyloid precursor protein (APP). The product of α-cleavage (sAPPα) has neuroprotective properties, while Aβ1-42 peptide, a product of β-cleavage, is neurotoxic. Dimerization of APP has been...

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Detalles Bibliográficos
Autores principales:	Libeu, Clare A. Peters, Descamps, Olivier, Zhang, Qiang, John, Varghese, Bredesen, Dale E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386930/ https://www.ncbi.nlm.nih.gov/pubmed/22768208 http://dx.doi.org/10.1371/journal.pone.0040027

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