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Interleukin-7 Regulates Adipose Tissue Mass and Insulin Sensitivity in High-Fat Diet-Fed Mice through Lymphocyte-Dependent and Independent Mechanisms

Although interleukin (IL)-7 is mostly known as a key regulator of lymphocyte homeostasis, we recently demonstrated that it also contributes to body weight regulation through a hypothalamic control. Previous studies have shown that IL-7 is produced by the human obese white adipose tissue (WAT) yet it...

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Autores principales: Lucas, Stéphanie, Taront, Solenne, Magnan, Christophe, Fauconnier, Laurence, Delacre, Myriam, Macia, Laurence, Delanoye, Anne, Verwaerde, Claudie, Spriet, Corentin, Saule, Pasquine, Goormachtigh, Gautier, Héliot, Laurent, Ktorza, Alain, Movassat, Jamileh, Polakowska, Renata, Auriault, Claude, Poulain-Godefroy, Odile, Di Santo, James, Froguel, Philippe, Wolowczuk, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386973/
https://www.ncbi.nlm.nih.gov/pubmed/22768283
http://dx.doi.org/10.1371/journal.pone.0040351
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author Lucas, Stéphanie
Taront, Solenne
Magnan, Christophe
Fauconnier, Laurence
Delacre, Myriam
Macia, Laurence
Delanoye, Anne
Verwaerde, Claudie
Spriet, Corentin
Saule, Pasquine
Goormachtigh, Gautier
Héliot, Laurent
Ktorza, Alain
Movassat, Jamileh
Polakowska, Renata
Auriault, Claude
Poulain-Godefroy, Odile
Di Santo, James
Froguel, Philippe
Wolowczuk, Isabelle
author_facet Lucas, Stéphanie
Taront, Solenne
Magnan, Christophe
Fauconnier, Laurence
Delacre, Myriam
Macia, Laurence
Delanoye, Anne
Verwaerde, Claudie
Spriet, Corentin
Saule, Pasquine
Goormachtigh, Gautier
Héliot, Laurent
Ktorza, Alain
Movassat, Jamileh
Polakowska, Renata
Auriault, Claude
Poulain-Godefroy, Odile
Di Santo, James
Froguel, Philippe
Wolowczuk, Isabelle
author_sort Lucas, Stéphanie
collection PubMed
description Although interleukin (IL)-7 is mostly known as a key regulator of lymphocyte homeostasis, we recently demonstrated that it also contributes to body weight regulation through a hypothalamic control. Previous studies have shown that IL-7 is produced by the human obese white adipose tissue (WAT) yet its potential role on WAT development and function in obesity remains unknown. Here, we first show that transgenic mice overexpressing IL-7 have reduced adipose tissue mass associated with glucose and insulin resistance. Moreover, in the high-fat diet (HFD)-induced obesity model, a single administration of IL-7 to C57BL/6 mice is sufficient to prevent HFD-induced WAT mass increase and glucose intolerance. This metabolic protective effect is accompanied by a significant decreased inflammation in WAT. In lymphocyte-deficient HFD-fed SCID mice, IL-7 injection still protects from WAT mass gain. However, IL-7-triggered resistance against WAT inflammation and glucose intolerance is lost in SCID mice. These results suggest that IL-7 regulates adipose tissue mass through a lymphocyte-independent mechanism while its protective role on glucose homeostasis would be relayed by immune cells that participate to WAT inflammation. Our observations establish a key role for IL-7 in the complex mechanisms by which immune mediators modulate metabolic functions.
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spelling pubmed-33869732012-07-05 Interleukin-7 Regulates Adipose Tissue Mass and Insulin Sensitivity in High-Fat Diet-Fed Mice through Lymphocyte-Dependent and Independent Mechanisms Lucas, Stéphanie Taront, Solenne Magnan, Christophe Fauconnier, Laurence Delacre, Myriam Macia, Laurence Delanoye, Anne Verwaerde, Claudie Spriet, Corentin Saule, Pasquine Goormachtigh, Gautier Héliot, Laurent Ktorza, Alain Movassat, Jamileh Polakowska, Renata Auriault, Claude Poulain-Godefroy, Odile Di Santo, James Froguel, Philippe Wolowczuk, Isabelle PLoS One Research Article Although interleukin (IL)-7 is mostly known as a key regulator of lymphocyte homeostasis, we recently demonstrated that it also contributes to body weight regulation through a hypothalamic control. Previous studies have shown that IL-7 is produced by the human obese white adipose tissue (WAT) yet its potential role on WAT development and function in obesity remains unknown. Here, we first show that transgenic mice overexpressing IL-7 have reduced adipose tissue mass associated with glucose and insulin resistance. Moreover, in the high-fat diet (HFD)-induced obesity model, a single administration of IL-7 to C57BL/6 mice is sufficient to prevent HFD-induced WAT mass increase and glucose intolerance. This metabolic protective effect is accompanied by a significant decreased inflammation in WAT. In lymphocyte-deficient HFD-fed SCID mice, IL-7 injection still protects from WAT mass gain. However, IL-7-triggered resistance against WAT inflammation and glucose intolerance is lost in SCID mice. These results suggest that IL-7 regulates adipose tissue mass through a lymphocyte-independent mechanism while its protective role on glucose homeostasis would be relayed by immune cells that participate to WAT inflammation. Our observations establish a key role for IL-7 in the complex mechanisms by which immune mediators modulate metabolic functions. Public Library of Science 2012-06-29 /pmc/articles/PMC3386973/ /pubmed/22768283 http://dx.doi.org/10.1371/journal.pone.0040351 Text en Lucas et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lucas, Stéphanie
Taront, Solenne
Magnan, Christophe
Fauconnier, Laurence
Delacre, Myriam
Macia, Laurence
Delanoye, Anne
Verwaerde, Claudie
Spriet, Corentin
Saule, Pasquine
Goormachtigh, Gautier
Héliot, Laurent
Ktorza, Alain
Movassat, Jamileh
Polakowska, Renata
Auriault, Claude
Poulain-Godefroy, Odile
Di Santo, James
Froguel, Philippe
Wolowczuk, Isabelle
Interleukin-7 Regulates Adipose Tissue Mass and Insulin Sensitivity in High-Fat Diet-Fed Mice through Lymphocyte-Dependent and Independent Mechanisms
title Interleukin-7 Regulates Adipose Tissue Mass and Insulin Sensitivity in High-Fat Diet-Fed Mice through Lymphocyte-Dependent and Independent Mechanisms
title_full Interleukin-7 Regulates Adipose Tissue Mass and Insulin Sensitivity in High-Fat Diet-Fed Mice through Lymphocyte-Dependent and Independent Mechanisms
title_fullStr Interleukin-7 Regulates Adipose Tissue Mass and Insulin Sensitivity in High-Fat Diet-Fed Mice through Lymphocyte-Dependent and Independent Mechanisms
title_full_unstemmed Interleukin-7 Regulates Adipose Tissue Mass and Insulin Sensitivity in High-Fat Diet-Fed Mice through Lymphocyte-Dependent and Independent Mechanisms
title_short Interleukin-7 Regulates Adipose Tissue Mass and Insulin Sensitivity in High-Fat Diet-Fed Mice through Lymphocyte-Dependent and Independent Mechanisms
title_sort interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386973/
https://www.ncbi.nlm.nih.gov/pubmed/22768283
http://dx.doi.org/10.1371/journal.pone.0040351
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