Cardiac Kallikrein-Kinin System Is Upregulated in Chronic Volume Overload and Mediates an Inflammatory Induced Collagen Loss

BACKGROUND: The clinical problem of a “pure volume overload” as in isolated mitral or aortic regurgitation currently has no documented medical therapy that attenuates collagen loss and the resultant left ventricular (LV) dilatation and failure. Here, we identify a potential mechanism related to upre...

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Detalles Bibliográficos
Autores principales: Wei, Chih-Chang, Chen, Yuanwen, Powell, Lindsay C., Zheng, Junying, Shi, Ke, Bradley, Wayne E., Powell, Pamela C., Ahmad, Sarfaraz, Ferrario, Carlos M., Dell’Italia, Louis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387019/
https://www.ncbi.nlm.nih.gov/pubmed/22768235
http://dx.doi.org/10.1371/journal.pone.0040110

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