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Small Molecules Targeted to a Non-Catalytic “RVxF” Binding Site of Protein Phosphatase-1 Inhibit HIV-1

HIV-1 Tat protein recruits host cell factors including CDK9/cyclin T1 to HIV-1 TAR RNA and thereby induces HIV-1 transcription. An interaction with host Ser/Thr protein phosphatase-1 (PP1) is critical for this function of Tat. PP1 binds to a Tat sequence, Q(35)VCF(38), which resembles the PP1-bindin...

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Detalles Bibliográficos
Autores principales:	Ammosova, Tatiana, Platonov, Maxim, Yedavalli, Venkat R. K., Obukhov, Yuri, Gordeuk, Victor R., Jeang, Kuan-Teh, Kovalskyy, Dmytro, Nekhai, Sergei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387161/ https://www.ncbi.nlm.nih.gov/pubmed/22768081 http://dx.doi.org/10.1371/journal.pone.0039481

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